Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case–control study
Abstract Background Brain tumor etiology is poorly understood. Based on their ability to pass through the blood–brain barrier, it has been hypothesized that exposure to metals may increase the risk of brain cancer. Results from the few epidemiological studies on this issue are limited and inconsiste...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | Environmental Health |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12940-017-0300-y |
| _version_ | 1811336690271256576 |
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| author | Marie-Elise Parent Michelle C. Turner Jérôme Lavoué Hugues Richard Jordi Figuerola Laurel Kincl Lesley Richardson Geza Benke Maria Blettner Sarah Fleming Martine Hours Daniel Krewski David McLean Siegal Sadetzki Klaus Schlaefer Brigitte Schlehofer Joachim Schüz Jack Siemiatycki Martie van Tongeren Elisabeth Cardis |
| author_facet | Marie-Elise Parent Michelle C. Turner Jérôme Lavoué Hugues Richard Jordi Figuerola Laurel Kincl Lesley Richardson Geza Benke Maria Blettner Sarah Fleming Martine Hours Daniel Krewski David McLean Siegal Sadetzki Klaus Schlaefer Brigitte Schlehofer Joachim Schüz Jack Siemiatycki Martie van Tongeren Elisabeth Cardis |
| author_sort | Marie-Elise Parent |
| collection | DOAJ |
| description | Abstract Background Brain tumor etiology is poorly understood. Based on their ability to pass through the blood–brain barrier, it has been hypothesized that exposure to metals may increase the risk of brain cancer. Results from the few epidemiological studies on this issue are limited and inconsistent. Methods We investigated the relationship between glioma risk and occupational exposure to five metals - lead, cadmium, nickel, chromium and iron- as well as to welding fumes, using data from the seven-country INTEROCC study. A total of 1800 incident glioma cases and 5160 controls aged 30–69 years were included in the analysis. Lifetime occupational exposure to the agents was assessed using the INTEROCC JEM, a modified version of the Finnish job exposure matrix FINJEM. Results In general, cases had a slightly higher prevalence of exposure to the various metals and welding fumes than did controls, with the prevalence among ever exposed ranging between 1.7 and 2.2% for cadmium to 10.2 and 13.6% for iron among controls and cases, respectively. However, in multivariable logistic regression analyses, there was no association between ever exposure to any of the agents and risk of glioma with odds ratios (95% confidence intervals) ranging from 0.8 (0.7–1.0) for lead to 1.1 (0.7–1.6) for cadmium. Results were consistent across models considering cumulative exposure or duration, as well as in all sensitivity analyses conducted. Conclusions Findings from this large-scale international study provide no evidence for an association between occupational exposure to any of the metals under scrutiny or welding fumes, and risk of glioma. |
| first_indexed | 2024-04-13T17:44:10Z |
| format | Article |
| id | doaj.art-4355a121613f4e70995058ce998ecfe1 |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-04-13T17:44:10Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-4355a121613f4e70995058ce998ecfe12022-12-22T02:37:05ZengBMCEnvironmental Health1476-069X2017-08-0116111010.1186/s12940-017-0300-yLifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case–control studyMarie-Elise Parent0Michelle C. Turner1Jérôme Lavoué2Hugues Richard3Jordi Figuerola4Laurel Kincl5Lesley Richardson6Geza Benke7Maria Blettner8Sarah Fleming9Martine Hours10Daniel Krewski11David McLean12Siegal Sadetzki13Klaus Schlaefer14Brigitte Schlehofer15Joachim Schüz16Jack Siemiatycki17Martie van Tongeren18Elisabeth Cardis19Epidemiology and Biostatistics Unit, INRS-Institut Armand-Frappier, Université du QuébecBarcelona Institute for Global Health (ISGlobal)School of Public Health, University of MontrealEpidemiology and Biostatistics Unit, INRS-Institut Armand-Frappier, Université du QuébecBarcelona Institute for Global Health (ISGlobal)Oregon State UniversityUniversity of Montreal Hospital Research Centre (CRCHUM)Monash UniversityInstitute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes-Gutenberg University MainzUniversity of LeedsUnité Mixte de Recherche Epidémiologique Transport Travail Environnement Université Lyon 1/IFSTTAR, Université de LyonMcLaughlin Centre for Population Health Risk Assessment, University of OttawaCentre for Public Health Research, Massey UniversityThe Cancer & Radiation Epidemiology Unit, The Gertner Institute, Chaim Sheba Medical CenterGerman Cancer Research Center (DKFZ)German Cancer Research Center (DKFZ)International Agency for Research on Cancer (IARC), Section of Environment and RadiationSchool of Public Health, University of MontrealInstitute of Occupational MedicineBarcelona Institute for Global Health (ISGlobal)Abstract Background Brain tumor etiology is poorly understood. Based on their ability to pass through the blood–brain barrier, it has been hypothesized that exposure to metals may increase the risk of brain cancer. Results from the few epidemiological studies on this issue are limited and inconsistent. Methods We investigated the relationship between glioma risk and occupational exposure to five metals - lead, cadmium, nickel, chromium and iron- as well as to welding fumes, using data from the seven-country INTEROCC study. A total of 1800 incident glioma cases and 5160 controls aged 30–69 years were included in the analysis. Lifetime occupational exposure to the agents was assessed using the INTEROCC JEM, a modified version of the Finnish job exposure matrix FINJEM. Results In general, cases had a slightly higher prevalence of exposure to the various metals and welding fumes than did controls, with the prevalence among ever exposed ranging between 1.7 and 2.2% for cadmium to 10.2 and 13.6% for iron among controls and cases, respectively. However, in multivariable logistic regression analyses, there was no association between ever exposure to any of the agents and risk of glioma with odds ratios (95% confidence intervals) ranging from 0.8 (0.7–1.0) for lead to 1.1 (0.7–1.6) for cadmium. Results were consistent across models considering cumulative exposure or duration, as well as in all sensitivity analyses conducted. Conclusions Findings from this large-scale international study provide no evidence for an association between occupational exposure to any of the metals under scrutiny or welding fumes, and risk of glioma.http://link.springer.com/article/10.1186/s12940-017-0300-yGliomaOccupational exposuresMetalsWelding fumes |
| spellingShingle | Marie-Elise Parent Michelle C. Turner Jérôme Lavoué Hugues Richard Jordi Figuerola Laurel Kincl Lesley Richardson Geza Benke Maria Blettner Sarah Fleming Martine Hours Daniel Krewski David McLean Siegal Sadetzki Klaus Schlaefer Brigitte Schlehofer Joachim Schüz Jack Siemiatycki Martie van Tongeren Elisabeth Cardis Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case–control study Environmental Health Glioma Occupational exposures Metals Welding fumes |
| title | Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case–control study |
| title_full | Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case–control study |
| title_fullStr | Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case–control study |
| title_full_unstemmed | Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case–control study |
| title_short | Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case–control study |
| title_sort | lifetime occupational exposure to metals and welding fumes and risk of glioma a 7 country population based case control study |
| topic | Glioma Occupational exposures Metals Welding fumes |
| url | http://link.springer.com/article/10.1186/s12940-017-0300-y |
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