Possible role of TCF7L2 in the pathogenesis of type 2 diabetes mellitus
With people's changing life style and dietary habits, the prevalence of type 2 diabetes mellitus (T2DM) has become much more serious than ever before. T2DM is a polygenic metabolic disorder, resulting from the interaction of genetic and various environmental factors. Among all the T2DM related...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-07-01
|
| Series: | Biotechnology & Biotechnological Equipment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/13102818.2018.1438211 |
| _version_ | 1828241720462016512 |
|---|---|
| author | Zhi-qiu Huang Yao-qi Liao Run-ze Huang Jin-peng Chen Hui-lin Sun |
| author_facet | Zhi-qiu Huang Yao-qi Liao Run-ze Huang Jin-peng Chen Hui-lin Sun |
| author_sort | Zhi-qiu Huang |
| collection | DOAJ |
| description | With people's changing life style and dietary habits, the prevalence of type 2 diabetes mellitus (T2DM) has become much more serious than ever before. T2DM is a polygenic metabolic disorder, resulting from the interaction of genetic and various environmental factors. Among all the T2DM related genes, the transcription factor 7 like 2 (TCF7L2) gene is one of the most relevant risk-related genes for T2DM. However, the role of TCF7L2 in T2DM pathogenesis has not yet been interpreted thoroughly. Based on the experimental studies in recent years, this review discusses several possible mechanisms of T2DM pathogenesis induced by TCF7L2. |
| first_indexed | 2024-04-12T22:03:52Z |
| format | Article |
| id | doaj.art-43575129d19e478390cfaac41a9f75e6 |
| institution | Directory Open Access Journal |
| issn | 1310-2818 1314-3530 |
| language | English |
| last_indexed | 2024-04-12T22:03:52Z |
| publishDate | 2018-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Biotechnology & Biotechnological Equipment |
| spelling | doaj.art-43575129d19e478390cfaac41a9f75e62022-12-22T03:15:00ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302018-07-0132483083410.1080/13102818.2018.14382111438211Possible role of TCF7L2 in the pathogenesis of type 2 diabetes mellitusZhi-qiu Huang0Yao-qi Liao1Run-ze Huang2Jin-peng Chen3Hui-lin Sun4The First Affiliated Hospital of Guangdong Pharmaceutical UniversityThe First Affiliated Hospital of Guangdong Pharmaceutical UniversityThe First Affiliated Hospital of Guangdong Pharmaceutical UniversityThe First Affiliated Hospital of Guangdong Pharmaceutical UniversityThe First Affiliated Hospital of Guangdong Pharmaceutical UniversityWith people's changing life style and dietary habits, the prevalence of type 2 diabetes mellitus (T2DM) has become much more serious than ever before. T2DM is a polygenic metabolic disorder, resulting from the interaction of genetic and various environmental factors. Among all the T2DM related genes, the transcription factor 7 like 2 (TCF7L2) gene is one of the most relevant risk-related genes for T2DM. However, the role of TCF7L2 in T2DM pathogenesis has not yet been interpreted thoroughly. Based on the experimental studies in recent years, this review discusses several possible mechanisms of T2DM pathogenesis induced by TCF7L2.http://dx.doi.org/10.1080/13102818.2018.1438211T2DMTCF7L2genetic mutationWnt signaling pathwayβ-cell apoptosisproinsulin conversionβ-cell responsiveness |
| spellingShingle | Zhi-qiu Huang Yao-qi Liao Run-ze Huang Jin-peng Chen Hui-lin Sun Possible role of TCF7L2 in the pathogenesis of type 2 diabetes mellitus Biotechnology & Biotechnological Equipment T2DM TCF7L2 genetic mutation Wnt signaling pathway β-cell apoptosis proinsulin conversion β-cell responsiveness |
| title | Possible role of TCF7L2 in the pathogenesis of type 2 diabetes mellitus |
| title_full | Possible role of TCF7L2 in the pathogenesis of type 2 diabetes mellitus |
| title_fullStr | Possible role of TCF7L2 in the pathogenesis of type 2 diabetes mellitus |
| title_full_unstemmed | Possible role of TCF7L2 in the pathogenesis of type 2 diabetes mellitus |
| title_short | Possible role of TCF7L2 in the pathogenesis of type 2 diabetes mellitus |
| title_sort | possible role of tcf7l2 in the pathogenesis of type 2 diabetes mellitus |
| topic | T2DM TCF7L2 genetic mutation Wnt signaling pathway β-cell apoptosis proinsulin conversion β-cell responsiveness |
| url | http://dx.doi.org/10.1080/13102818.2018.1438211 |
| work_keys_str_mv | AT zhiqiuhuang possibleroleoftcf7l2inthepathogenesisoftype2diabetesmellitus AT yaoqiliao possibleroleoftcf7l2inthepathogenesisoftype2diabetesmellitus AT runzehuang possibleroleoftcf7l2inthepathogenesisoftype2diabetesmellitus AT jinpengchen possibleroleoftcf7l2inthepathogenesisoftype2diabetesmellitus AT huilinsun possibleroleoftcf7l2inthepathogenesisoftype2diabetesmellitus |