Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID‐19 era: A systematic‐review
Abstract Background The recent outbreak of Human Monkeypox (MPXV) in nonendemic regions of the world is of great concern. Objective We aimed to systematically analyze the current epidemiology, clinical presentation, and outcomes of the Monkeypox virus. Method Systematic literature was conducted in P...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.722 |
| _version_ | 1797989886547984384 |
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| author | Vikash Jaiswal Priyanshu Nain Dattatreya Mukherjee Amey Joshi Mittal Savaliya Angela Ishak Nitya Batra Dipansha Maroo Deepak Verma |
| author_facet | Vikash Jaiswal Priyanshu Nain Dattatreya Mukherjee Amey Joshi Mittal Savaliya Angela Ishak Nitya Batra Dipansha Maroo Deepak Verma |
| author_sort | Vikash Jaiswal |
| collection | DOAJ |
| description | Abstract Background The recent outbreak of Human Monkeypox (MPXV) in nonendemic regions of the world is of great concern. Objective We aimed to systematically analyze the current epidemiology, clinical presentation, and outcomes of the Monkeypox virus. Method Systematic literature was conducted in PubMed, Embase, Google Scholar, and Scopus using predefined MESH terms by using “AND” and “OR.” The following search terms were used: Monkeypox [MeSH] OR “Monkeypox virus” [MeSH] OR “POX” OR “Monkeypox” AND “Outbreak” AND “Outcomes” from December 2019 till 14th June 2022 without restrictions of language. Results A total of 1074 (99.90%) patients tested positive for Monkeypox virus through RT‐PCR while 1 (0.09) patient was suspected. There was a gender difference with male predominance (54.23% vs. 45.48%) compared with female patients. Mean age (±SD) of patients was 20.66 ± 16.45 years. The major symptoms were rash (100%), fever (96%), and other important symptoms were upper respiratory symptoms (97%), headache (95%), vomiting (95%), oral ulcers (96%), conjunctivitis (96%) and lymphadenopathy (85%). The average mean duration of treatment was 5 days, while the mean hospitalization duration was 13.3 ± 6.37 days. The outcome of 20 patients was available, 19 of 20 patients recovered fully from monkeypox, however, 1 patient was not able to survive resulting in death. Conclusion The recent monkeypox virus outbreak has shown that the virus could transmit in ways that were not previously expected. Further research is needed to understand the possible outcomes and association with humans and their different organ systems. |
| first_indexed | 2024-04-11T08:27:48Z |
| format | Article |
| id | doaj.art-43589941162c4b96bb8da634cd6d461d |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-04-11T08:27:48Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-43589941162c4b96bb8da634cd6d461d2022-12-22T04:34:40ZengWileyImmunity, Inflammation and Disease2050-45272022-11-011011n/an/a10.1002/iid3.722Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID‐19 era: A systematic‐reviewVikash Jaiswal0Priyanshu Nain1Dattatreya Mukherjee2Amey Joshi3Mittal Savaliya4Angela Ishak5Nitya Batra6Dipansha Maroo7Deepak Verma8Department of Research Larkin Community Hospital South Miami Florida USADepartment of Medicine Maulana Azad Medical College New Delhi IndiaDepartment of Medicine Raiganj Government Medical College and Hospital Raiganj West Bengal IndiaDepartment of Research Larkin Community Hospital South Miami Florida USADepartment of Medicine GMERS Medical College Junagadh Gujarat IndiaDepartment of Research Larkin Community Hospital South Miami Fl USADepartment of Medicine Maulana Azad Medical College New Delhi IndiaDepartment of Medicine Maulana Azad Medical College New Delhi IndiaDepartment of Medicine Janaki Medical College Dhanusha NepalAbstract Background The recent outbreak of Human Monkeypox (MPXV) in nonendemic regions of the world is of great concern. Objective We aimed to systematically analyze the current epidemiology, clinical presentation, and outcomes of the Monkeypox virus. Method Systematic literature was conducted in PubMed, Embase, Google Scholar, and Scopus using predefined MESH terms by using “AND” and “OR.” The following search terms were used: Monkeypox [MeSH] OR “Monkeypox virus” [MeSH] OR “POX” OR “Monkeypox” AND “Outbreak” AND “Outcomes” from December 2019 till 14th June 2022 without restrictions of language. Results A total of 1074 (99.90%) patients tested positive for Monkeypox virus through RT‐PCR while 1 (0.09) patient was suspected. There was a gender difference with male predominance (54.23% vs. 45.48%) compared with female patients. Mean age (±SD) of patients was 20.66 ± 16.45 years. The major symptoms were rash (100%), fever (96%), and other important symptoms were upper respiratory symptoms (97%), headache (95%), vomiting (95%), oral ulcers (96%), conjunctivitis (96%) and lymphadenopathy (85%). The average mean duration of treatment was 5 days, while the mean hospitalization duration was 13.3 ± 6.37 days. The outcome of 20 patients was available, 19 of 20 patients recovered fully from monkeypox, however, 1 patient was not able to survive resulting in death. Conclusion The recent monkeypox virus outbreak has shown that the virus could transmit in ways that were not previously expected. Further research is needed to understand the possible outcomes and association with humans and their different organ systems.https://doi.org/10.1002/iid3.722infectionmonkeypox virusoutcomespathology |
| spellingShingle | Vikash Jaiswal Priyanshu Nain Dattatreya Mukherjee Amey Joshi Mittal Savaliya Angela Ishak Nitya Batra Dipansha Maroo Deepak Verma Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID‐19 era: A systematic‐review Immunity, Inflammation and Disease infection monkeypox virus outcomes pathology |
| title | Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID‐19 era: A systematic‐review |
| title_full | Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID‐19 era: A systematic‐review |
| title_fullStr | Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID‐19 era: A systematic‐review |
| title_full_unstemmed | Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID‐19 era: A systematic‐review |
| title_short | Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID‐19 era: A systematic‐review |
| title_sort | symptomatology prognosis and clinical findings of monkeypox infected patients during covid 19 era a systematic review |
| topic | infection monkeypox virus outcomes pathology |
| url | https://doi.org/10.1002/iid3.722 |
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