Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice

Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice

The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to a...

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Bibliographic Details
Main Authors: Marina V. Kovina, Alexey V. Karnaukhov, Mikhail E. Krasheninnikov, Artem L. Kovin, Sarul T. Gazheev, Larisa A. Sergievich, Elena V. Karnaukhova, Elena V. Bogdanenko, Maxim V. Balyasin, Yury M. Khodarovich, Tatyana G. Dyuzheva, Alexey V. Lyundup
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Genetics
Subjects:
bone marrow transplantation
mesenchymal stem cells
longevity
life extension
cryobank
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00310/full

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