Development of a versatile and conventional technique for gene disruption in filamentous fungi based on CRISPR-Cas9 technology

Development of a versatile and conventional technique for gene disruption in filamentous fungi based on CRISPR-Cas9 technology

Abstract Filamentous fungi represent an invaluable source of pharmaceutically active compounds. The development of versatile methods to genetically manipulate filamentous fungi is of great value for improving the low yields of bioactive metabolites and expanding chemical diversity. The CRISPR-Cas9-b...

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Bibliographic Details
Main Authors: Yan-Mei Zheng, Fu-Long Lin, Hao Gao, Gen Zou, Jiang-Wei Zhang, Gao-Qian Wang, Guo-Dong Chen, Zhi-Hua Zhou, Xin-Sheng Yao, Dan Hu
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-10052-3

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