Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.

Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.

Steroid and xenobiotic receptor (SXR) and its murine ortholog, pregnane X receptor (PXR), are nuclear receptors that are expressed at high levels in the liver and the intestine where they function as xenobiotic sensors that induce expression of genes involved in detoxification and drug excretion. Re...

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Bibliographic Details
Main Authors: Kotaro Azuma, Stephanie C Casey, Tomohiko Urano, Kuniko Horie-Inoue, Yasuyoshi Ouchi, Bruce Blumberg, Satoshi Inoue
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0119177

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