Ultrasensitive and rapid detection of hydrogen sulfide by an upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4@Ag2O
Hydrogen sulfide (H2S), a third gas signaling molecule, is considered to play a vital role in the development and treatment of diseases. To elucidate the intricate role of H2S in the organism and its participation in disease processes, there is an urgent need to visualize the dynamics of H2S. Howeve...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523009620 |
| _version_ | 1797347808221593600 |
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| author | Shuai Zha Siyu Pan Yuehan Jian Yunhui Peng Lijun Jiang |
| author_facet | Shuai Zha Siyu Pan Yuehan Jian Yunhui Peng Lijun Jiang |
| author_sort | Shuai Zha |
| collection | DOAJ |
| description | Hydrogen sulfide (H2S), a third gas signaling molecule, is considered to play a vital role in the development and treatment of diseases. To elucidate the intricate role of H2S in the organism and its participation in disease processes, there is an urgent need to visualize the dynamics of H2S. However, most currently available molecular probes have limitations in terms of sensitivity, specificity, and precision. In this study, the safe and biocompatible upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4 anchored with Ag2O was successfully fabricated for H2S detection with an ultralow detection limit at 0.93 ng/mL. NaYF4:Yb3+, Tm3+@NaYF4@Ag2S is formed through in situ sulfuration reaction, and second near-infrared (NIR-II) fluorescence can be recorded upon the presence of H2S under 808 nm excitation. The results demonstrate the exceptional detection linearity and high specificity for H2S quantification. Additionally, NaYF4:Yb3+, Tm3+@NaYF4@Ag2O possesses a safe nature in normal and cancer cells. This nanosensor presents a NIR fluorescence imaging strategy for highly sensitive and specific detection of H2S, which has promises to be a practical tool for biomedical applications. |
| first_indexed | 2024-03-08T11:54:18Z |
| format | Article |
| id | doaj.art-435e3795de1f40419b976a0d3ed13aa1 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-08T11:54:18Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-435e3795de1f40419b976a0d3ed13aa12024-01-24T05:16:16ZengElsevierMaterials & Design0264-12752024-01-01237112546Ultrasensitive and rapid detection of hydrogen sulfide by an upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4@Ag2OShuai Zha0Siyu Pan1Yuehan Jian2Yunhui Peng3Lijun Jiang4School of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan 430065, China; Hubei Shizhen Laboratory, Wuhan 430061, China; Corresponding authors.Hubei Key Laboratory of Genetic Regulation & Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, ChinaHubei Key Laboratory of Genetic Regulation & Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, ChinaInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, ChinaHubei Key Laboratory of Genetic Regulation & Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, China; Corresponding authors.Hydrogen sulfide (H2S), a third gas signaling molecule, is considered to play a vital role in the development and treatment of diseases. To elucidate the intricate role of H2S in the organism and its participation in disease processes, there is an urgent need to visualize the dynamics of H2S. However, most currently available molecular probes have limitations in terms of sensitivity, specificity, and precision. In this study, the safe and biocompatible upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4 anchored with Ag2O was successfully fabricated for H2S detection with an ultralow detection limit at 0.93 ng/mL. NaYF4:Yb3+, Tm3+@NaYF4@Ag2S is formed through in situ sulfuration reaction, and second near-infrared (NIR-II) fluorescence can be recorded upon the presence of H2S under 808 nm excitation. The results demonstrate the exceptional detection linearity and high specificity for H2S quantification. Additionally, NaYF4:Yb3+, Tm3+@NaYF4@Ag2O possesses a safe nature in normal and cancer cells. This nanosensor presents a NIR fluorescence imaging strategy for highly sensitive and specific detection of H2S, which has promises to be a practical tool for biomedical applications.http://www.sciencedirect.com/science/article/pii/S0264127523009620Lanthanide nanosensorUpconversion emissionNIR-II fluorescenceH2S detectionEndogenous H2S activated nanosensor |
| spellingShingle | Shuai Zha Siyu Pan Yuehan Jian Yunhui Peng Lijun Jiang Ultrasensitive and rapid detection of hydrogen sulfide by an upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4@Ag2O Materials & Design Lanthanide nanosensor Upconversion emission NIR-II fluorescence H2S detection Endogenous H2S activated nanosensor |
| title | Ultrasensitive and rapid detection of hydrogen sulfide by an upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4@Ag2O |
| title_full | Ultrasensitive and rapid detection of hydrogen sulfide by an upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4@Ag2O |
| title_fullStr | Ultrasensitive and rapid detection of hydrogen sulfide by an upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4@Ag2O |
| title_full_unstemmed | Ultrasensitive and rapid detection of hydrogen sulfide by an upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4@Ag2O |
| title_short | Ultrasensitive and rapid detection of hydrogen sulfide by an upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4@Ag2O |
| title_sort | ultrasensitive and rapid detection of hydrogen sulfide by an upconversion nanosensor nayf4 yb3 tm3 nayf4 ag2o |
| topic | Lanthanide nanosensor Upconversion emission NIR-II fluorescence H2S detection Endogenous H2S activated nanosensor |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523009620 |
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