Benzimidazoles cause lethality by inhibiting the function of Caenorhabditis elegans neuronal beta-tubulin

Benzimidazoles cause lethality by inhibiting the function of Caenorhabditis elegans neuronal beta-tubulin

Parasitic nematode infections cause an enormous global burden to both humans and livestock. Resistance to the limited arsenal of anthelmintic drugs used to combat these infections is widespread, including benzimidazole (BZ) compounds. Previous studies using the free-living nematode Caenorhabditis el...

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Bibliographic Details
Main Authors: Sophia B. Gibson, Elan Ness-Cohn, Erik C. Andersen
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Benzimidazole resistance
C.elegans
High-throughput assay
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320722000252

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