The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface

The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface

To establish a healthy pregnancy, maternal immune cells must tolerate fetal allo-antigens and remain competent to respond to infections both systemically and in placental tissues. Extravillous trophoblasts (EVT) are the most invasive cells of extra-embryonic origin to invade uterine tissues and expr...

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Bibliographic Details
Main Authors: Henrieta Papúchová, Torsten B. Meissner, Qin Li, Jack L. Strominger, Tamara Tilburgs
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
human
pregnancy
decidua
regulatory T cells
effector T cells
decidual NK cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02730/full

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