Tuning the Physically Induced Crystallinity of Microfabricated Bioresorbable Guides for Insertion of Flexible Neural Implants
Abstract Devices that safely interface with the brain are critical to advancing neuroengineering. Thin and flexible neural implants show great promise alongside established silicon technologies. They therefore require a physical stiffener to allow their insertion into brain tissue. Bioresorbable pol...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2024-03-01
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| Series: | Advanced Materials Interfaces |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/admi.202300978 |
| _version_ | 1797248804771069952 |
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| author | Hajar Mousavi Emmie Schoutens Amira El Merhie Gabriel Dieuset Gautier Dauly Marina Galliani Fabrice Wendling Esma Ismailova |
| author_facet | Hajar Mousavi Emmie Schoutens Amira El Merhie Gabriel Dieuset Gautier Dauly Marina Galliani Fabrice Wendling Esma Ismailova |
| author_sort | Hajar Mousavi |
| collection | DOAJ |
| description | Abstract Devices that safely interface with the brain are critical to advancing neuroengineering. Thin and flexible neural implants show great promise alongside established silicon technologies. They therefore require a physical stiffener to allow their insertion into brain tissue. Bioresorbable polymer shanks are novel transient guides enabling accurate implantation using biocompatible materials that will be absorbed by the body over time. The development of materials with optimized stiffness and degradation is needed to provide minimally invasive probes with precise insertion capability under surgical conditions. A microfabrication protocol for the patterning of polyvinyl alcohol and its physical cross‐linking is presented, resulting in insertion guides with precise shapes and tunable degradation and stiffness. The results demonstrate a remarkable improvement in batch fabricating micro‐scale neural shanks with designed crystallinity. It results in their prolonged degradation time, evaluated in agarose gel, and remarkably improved penetrability due to the increase in mechanical stiffness. In vitro and in vivo studies support the high acceptability of this combination in interfacing with neural cells and tissue. This work represents a novel approach to the material and process engineering of bioresorbable polymers for developing fully organic and safe implants. |
| first_indexed | 2024-04-24T20:20:25Z |
| format | Article |
| id | doaj.art-4361f4c22f9d479596f142ea018a9bd5 |
| institution | Directory Open Access Journal |
| issn | 2196-7350 |
| language | English |
| last_indexed | 2024-04-24T20:20:25Z |
| publishDate | 2024-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj.art-4361f4c22f9d479596f142ea018a9bd52024-03-22T08:17:41ZengWiley-VCHAdvanced Materials Interfaces2196-73502024-03-01119n/an/a10.1002/admi.202300978Tuning the Physically Induced Crystallinity of Microfabricated Bioresorbable Guides for Insertion of Flexible Neural ImplantsHajar Mousavi0Emmie Schoutens1Amira El Merhie2Gabriel Dieuset3Gautier Dauly4Marina Galliani5Fabrice Wendling6Esma Ismailova7Département BEL, Centre CMP Mines Saint‐Etienne Gardanne F‐13541 FranceDépartement BEL, Centre CMP Mines Saint‐Etienne Gardanne F‐13541 FranceDépartement BEL, Centre CMP Mines Saint‐Etienne Gardanne F‐13541 FranceInsermUniversity of RennesLTSI‐U1099 Rennes 3500 FranceInsermUniversity of RennesLTSI‐U1099 Rennes 3500 FranceDépartement BEL, Centre CMP Mines Saint‐Etienne Gardanne F‐13541 FranceInsermUniversity of RennesLTSI‐U1099 Rennes 3500 FranceDépartement BEL, Centre CMP Mines Saint‐Etienne Gardanne F‐13541 FranceAbstract Devices that safely interface with the brain are critical to advancing neuroengineering. Thin and flexible neural implants show great promise alongside established silicon technologies. They therefore require a physical stiffener to allow their insertion into brain tissue. Bioresorbable polymer shanks are novel transient guides enabling accurate implantation using biocompatible materials that will be absorbed by the body over time. The development of materials with optimized stiffness and degradation is needed to provide minimally invasive probes with precise insertion capability under surgical conditions. A microfabrication protocol for the patterning of polyvinyl alcohol and its physical cross‐linking is presented, resulting in insertion guides with precise shapes and tunable degradation and stiffness. The results demonstrate a remarkable improvement in batch fabricating micro‐scale neural shanks with designed crystallinity. It results in their prolonged degradation time, evaluated in agarose gel, and remarkably improved penetrability due to the increase in mechanical stiffness. In vitro and in vivo studies support the high acceptability of this combination in interfacing with neural cells and tissue. This work represents a novel approach to the material and process engineering of bioresorbable polymers for developing fully organic and safe implants.https://doi.org/10.1002/admi.202300978bioresorbable shanksflexible neural implantsphysical cross‐linkingpolyvinyl alcohol |
| spellingShingle | Hajar Mousavi Emmie Schoutens Amira El Merhie Gabriel Dieuset Gautier Dauly Marina Galliani Fabrice Wendling Esma Ismailova Tuning the Physically Induced Crystallinity of Microfabricated Bioresorbable Guides for Insertion of Flexible Neural Implants Advanced Materials Interfaces bioresorbable shanks flexible neural implants physical cross‐linking polyvinyl alcohol |
| title | Tuning the Physically Induced Crystallinity of Microfabricated Bioresorbable Guides for Insertion of Flexible Neural Implants |
| title_full | Tuning the Physically Induced Crystallinity of Microfabricated Bioresorbable Guides for Insertion of Flexible Neural Implants |
| title_fullStr | Tuning the Physically Induced Crystallinity of Microfabricated Bioresorbable Guides for Insertion of Flexible Neural Implants |
| title_full_unstemmed | Tuning the Physically Induced Crystallinity of Microfabricated Bioresorbable Guides for Insertion of Flexible Neural Implants |
| title_short | Tuning the Physically Induced Crystallinity of Microfabricated Bioresorbable Guides for Insertion of Flexible Neural Implants |
| title_sort | tuning the physically induced crystallinity of microfabricated bioresorbable guides for insertion of flexible neural implants |
| topic | bioresorbable shanks flexible neural implants physical cross‐linking polyvinyl alcohol |
| url | https://doi.org/10.1002/admi.202300978 |
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