Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls
Abstract There has been little analysis of neurochemical correlates of compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) to assess the balance of excitatory and inhibitory neurotransmission by measuring glutamate and G...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-38695-z |
| _version_ | 1797789625722339328 |
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| author | Marjan Biria Paula Banca Máiréad P. Healy Engin Keser Stephen J. Sawiak Christopher T. Rodgers Catarina Rua Ana Maria Frota Lisbôa Pereira de Souza Aleya A. Marzuki Akeem Sule Karen D. Ersche Trevor W. Robbins |
| author_facet | Marjan Biria Paula Banca Máiréad P. Healy Engin Keser Stephen J. Sawiak Christopher T. Rodgers Catarina Rua Ana Maria Frota Lisbôa Pereira de Souza Aleya A. Marzuki Akeem Sule Karen D. Ersche Trevor W. Robbins |
| author_sort | Marjan Biria |
| collection | DOAJ |
| description | Abstract There has been little analysis of neurochemical correlates of compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) to assess the balance of excitatory and inhibitory neurotransmission by measuring glutamate and GABA levels in anterior cingulate cortex (ACC) and supplementary motor area (SMA) of healthy volunteers and participants with Obsessive-Compulsive Disorder (OCD). Within the SMA, trait and clinical measures of compulsive behaviour are related to glutamate levels, whereas a behavioural index of habitual control correlates with the glutamate:GABA ratio. Participants with OCD also show the latter relationship in the ACC while exhibiting elevated glutamate and lower GABA levels in that region. This study highlights SMA mechanisms of habitual control relevant to compulsive behaviour, common to the healthy sub-clinical and OCD populations. The results also demonstrate additional involvement of anterior cingulate in the balance between goal-directed and habitual responding in OCD. |
| first_indexed | 2024-03-13T01:53:20Z |
| format | Article |
| id | doaj.art-4362de58315642999a573eeeb8c4ec77 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-13T01:53:20Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4362de58315642999a573eeeb8c4ec772023-07-02T11:20:46ZengNature PortfolioNature Communications2041-17232023-06-0114111310.1038/s41467-023-38695-zCortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controlsMarjan Biria0Paula Banca1Máiréad P. Healy2Engin Keser3Stephen J. Sawiak4Christopher T. Rodgers5Catarina Rua6Ana Maria Frota Lisbôa Pereira de Souza7Aleya A. Marzuki8Akeem Sule9Karen D. Ersche10Trevor W. Robbins11Department of Psychology, University of CambridgeDepartment of Psychology, University of CambridgeDepartment of Psychology, University of CambridgeDepartment of Psychology, University of CambridgeBehavioural and Clinical Neuroscience Institute, University of CambridgeWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of CambridgeWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of CambridgeDepartment of Psychology, University of CambridgeDepartment of Psychology, University of CambridgeDepartment of Psychiatry, School of Clinical Medicine, University of CambridgeDepartment of Psychiatry, School of Clinical Medicine, University of CambridgeDepartment of Psychology, University of CambridgeAbstract There has been little analysis of neurochemical correlates of compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) to assess the balance of excitatory and inhibitory neurotransmission by measuring glutamate and GABA levels in anterior cingulate cortex (ACC) and supplementary motor area (SMA) of healthy volunteers and participants with Obsessive-Compulsive Disorder (OCD). Within the SMA, trait and clinical measures of compulsive behaviour are related to glutamate levels, whereas a behavioural index of habitual control correlates with the glutamate:GABA ratio. Participants with OCD also show the latter relationship in the ACC while exhibiting elevated glutamate and lower GABA levels in that region. This study highlights SMA mechanisms of habitual control relevant to compulsive behaviour, common to the healthy sub-clinical and OCD populations. The results also demonstrate additional involvement of anterior cingulate in the balance between goal-directed and habitual responding in OCD.https://doi.org/10.1038/s41467-023-38695-z |
| spellingShingle | Marjan Biria Paula Banca Máiréad P. Healy Engin Keser Stephen J. Sawiak Christopher T. Rodgers Catarina Rua Ana Maria Frota Lisbôa Pereira de Souza Aleya A. Marzuki Akeem Sule Karen D. Ersche Trevor W. Robbins Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls Nature Communications |
| title | Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls |
| title_full | Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls |
| title_fullStr | Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls |
| title_full_unstemmed | Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls |
| title_short | Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls |
| title_sort | cortical glutamate and gaba are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls |
| url | https://doi.org/10.1038/s41467-023-38695-z |
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