Comparison of Trazodone, Diazepame and Dibenzepine Influences on Rat Brain Beta-Endorphins Content
The aim of our study was to establish the extent of influence of different psychotropic drugs to brain β-endorphins in experimental animals. The study was performed on albino Wistar rats (weight 250 g), treated with different psychoactive drugs. RIA technique was employed for quantification of brai...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2007-08-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3048 |
| _version_ | 1797260815633481728 |
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| author | Radivoj Jadrić Sabaheta Hasić Emina Kiseljaković Mira Winterhalter-Jadrić |
| author_facet | Radivoj Jadrić Sabaheta Hasić Emina Kiseljaković Mira Winterhalter-Jadrić |
| author_sort | Radivoj Jadrić |
| collection | DOAJ |
| description |
The aim of our study was to establish the extent of influence of different psychotropic drugs to brain β-endorphins in experimental animals. The study was performed on albino Wistar rats (weight 250 g), treated with different psychoactive drugs. RIA technique was employed for quantification of brain β-endorphins. Brain β-endorphins were higher in experiment group treated with trazodone (929 pg/g ± 44,43; X±SD), and dibenzepine (906,63 pg/g ± 74,06), yet with lower brain content in rats treated with diazepame (841,55 pg/g ± 68,47), compared to brain β-endorphins content of control group treated with saline solution (0,95% NaCl) (873,5 pg/g ± 44,89). Significant differences were obtained comparing brain β-endorphins of trazodone vs. diaze-pame treated animals, with diazepame group having lower values (p<0,02). This study showed differences in changes of rat brain β-endorphins contents when different psy-choactive drugs are used. Therefore, we consider that β-endorphins could be used for evaluation of effects of psychoactive drugs, as a useful parameter in therapy with these psycho pharmaceuticals.
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| first_indexed | 2024-04-24T23:31:19Z |
| format | Article |
| id | doaj.art-4362e67727a74269bd19447694e9388b |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:31:19Z |
| publishDate | 2007-08-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-4362e67727a74269bd19447694e9388b2024-03-15T14:38:14ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2007-08-017310.17305/bjbms.2007.3048621Comparison of Trazodone, Diazepame and Dibenzepine Influences on Rat Brain Beta-Endorphins ContentRadivoj Jadrić0Sabaheta Hasić1Emina Kiseljaković2Mira Winterhalter-Jadrić3Institute for Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute for Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute for Physiology and Biochemistry, Faculty of Medicine, University of SarajevoInstitute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo The aim of our study was to establish the extent of influence of different psychotropic drugs to brain β-endorphins in experimental animals. The study was performed on albino Wistar rats (weight 250 g), treated with different psychoactive drugs. RIA technique was employed for quantification of brain β-endorphins. Brain β-endorphins were higher in experiment group treated with trazodone (929 pg/g ± 44,43; X±SD), and dibenzepine (906,63 pg/g ± 74,06), yet with lower brain content in rats treated with diazepame (841,55 pg/g ± 68,47), compared to brain β-endorphins content of control group treated with saline solution (0,95% NaCl) (873,5 pg/g ± 44,89). Significant differences were obtained comparing brain β-endorphins of trazodone vs. diaze-pame treated animals, with diazepame group having lower values (p<0,02). This study showed differences in changes of rat brain β-endorphins contents when different psy-choactive drugs are used. Therefore, we consider that β-endorphins could be used for evaluation of effects of psychoactive drugs, as a useful parameter in therapy with these psycho pharmaceuticals. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3048β-endorphinsratpsychotropic drugstrazodonediazepamediben-zepine |
| spellingShingle | Radivoj Jadrić Sabaheta Hasić Emina Kiseljaković Mira Winterhalter-Jadrić Comparison of Trazodone, Diazepame and Dibenzepine Influences on Rat Brain Beta-Endorphins Content Biomolecules & Biomedicine β-endorphins rat psychotropic drugs trazodone diazepame diben-zepine |
| title | Comparison of Trazodone, Diazepame and Dibenzepine Influences on Rat Brain Beta-Endorphins Content |
| title_full | Comparison of Trazodone, Diazepame and Dibenzepine Influences on Rat Brain Beta-Endorphins Content |
| title_fullStr | Comparison of Trazodone, Diazepame and Dibenzepine Influences on Rat Brain Beta-Endorphins Content |
| title_full_unstemmed | Comparison of Trazodone, Diazepame and Dibenzepine Influences on Rat Brain Beta-Endorphins Content |
| title_short | Comparison of Trazodone, Diazepame and Dibenzepine Influences on Rat Brain Beta-Endorphins Content |
| title_sort | comparison of trazodone diazepame and dibenzepine influences on rat brain beta endorphins content |
| topic | β-endorphins rat psychotropic drugs trazodone diazepame diben-zepine |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3048 |
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