Light chain proximal tubulopathy with lambda restriction presenting as acute kidney injury
Monoclonal gammopathies can produce a variety of glomerular, tubular, vascular and interstitial lesions. The spectrums of renal lesions produced by these monoclonal gammopathies include AL/AH amyloidosis, light chain cast nephropathy or myeloma kidney and various proximal tubulopathies. Out of these...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2021-07-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-10-e35.pdf |
| _version_ | 1827948608844988416 |
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| author | Asha Thomas Ram Prasad Elumalai Barathi Gunabooshanam Subalakshmi Balasubramanian Jayakumar Matcha |
| author_facet | Asha Thomas Ram Prasad Elumalai Barathi Gunabooshanam Subalakshmi Balasubramanian Jayakumar Matcha |
| author_sort | Asha Thomas |
| collection | DOAJ |
| description | Monoclonal gammopathies can produce a variety of glomerular, tubular, vascular and interstitial lesions. The spectrums of renal lesions produced by these monoclonal gammopathies include AL/AH amyloidosis, light chain cast nephropathy or myeloma kidney and various proximal tubulopathies. Out of these, proximal tubule centered lesions are much less identified and diagnosed and light chain proximal tubulopathy (LCPT) is one among them. In LCPT the excess free light chains (mostly kappa type by immunofluorescence microscopy) in serum are filtered by the glomeruli and are reabsorbed by proximal tubules causing its damage. These monoclonal light chains when sequestered in the proximal tubules can give rise to crystalline and noncrystalline histological variants. Here we present a rare case of noncrystalline variant of LCPT with lambda light chain restriction who presented with renal insufficiency which on later investigations revealed to be multiple myeloma. |
| first_indexed | 2024-04-09T12:58:02Z |
| format | Article |
| id | doaj.art-4364bca20b4d4b088fb4c1e9fa3e07d3 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:58:02Z |
| publishDate | 2021-07-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-4364bca20b4d4b088fb4c1e9fa3e07d32023-05-13T11:24:47ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192021-07-01103e35e3510.34172/jnp.2021.35jnp-16066Light chain proximal tubulopathy with lambda restriction presenting as acute kidney injuryAsha Thomas0Ram Prasad Elumalai1Barathi Gunabooshanam2Subalakshmi Balasubramanian3Jayakumar Matcha4Department of Nephrology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, IndiaDepartment of Nephrology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, IndiaDepartment of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, IndiaDepartment of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, IndiaDepartment of Nephrology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, IndiaMonoclonal gammopathies can produce a variety of glomerular, tubular, vascular and interstitial lesions. The spectrums of renal lesions produced by these monoclonal gammopathies include AL/AH amyloidosis, light chain cast nephropathy or myeloma kidney and various proximal tubulopathies. Out of these, proximal tubule centered lesions are much less identified and diagnosed and light chain proximal tubulopathy (LCPT) is one among them. In LCPT the excess free light chains (mostly kappa type by immunofluorescence microscopy) in serum are filtered by the glomeruli and are reabsorbed by proximal tubules causing its damage. These monoclonal light chains when sequestered in the proximal tubules can give rise to crystalline and noncrystalline histological variants. Here we present a rare case of noncrystalline variant of LCPT with lambda light chain restriction who presented with renal insufficiency which on later investigations revealed to be multiple myeloma.https://nephropathol.com/PDF/jnp-10-e35.pdflight chain proximal tubulopathylambda restrictionmultiple myeloma |
| spellingShingle | Asha Thomas Ram Prasad Elumalai Barathi Gunabooshanam Subalakshmi Balasubramanian Jayakumar Matcha Light chain proximal tubulopathy with lambda restriction presenting as acute kidney injury Journal of Nephropathology light chain proximal tubulopathy lambda restriction multiple myeloma |
| title | Light chain proximal tubulopathy with lambda restriction presenting as acute kidney injury |
| title_full | Light chain proximal tubulopathy with lambda restriction presenting as acute kidney injury |
| title_fullStr | Light chain proximal tubulopathy with lambda restriction presenting as acute kidney injury |
| title_full_unstemmed | Light chain proximal tubulopathy with lambda restriction presenting as acute kidney injury |
| title_short | Light chain proximal tubulopathy with lambda restriction presenting as acute kidney injury |
| title_sort | light chain proximal tubulopathy with lambda restriction presenting as acute kidney injury |
| topic | light chain proximal tubulopathy lambda restriction multiple myeloma |
| url | https://nephropathol.com/PDF/jnp-10-e35.pdf |
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