Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression
The SOX18 transcription factor plays an important role in endothelial cell specification, angiogenesis and atherogenesis. By profiling transcription factor interactions (TranSignal TM TF Protein Array) we identified several transcription factors implicated in angiogenesis that have the ability to...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2011-01-01
|
| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641103517P.pdf |
| _version_ | 1818608366364131328 |
|---|---|
| author | Petrović Isidora Kovačević-Grujičić Nataša Popović Jelena Krstić A. Milivojević Milena Stevanović Milena |
| author_facet | Petrović Isidora Kovačević-Grujičić Nataša Popović Jelena Krstić A. Milivojević Milena Stevanović Milena |
| author_sort | Petrović Isidora |
| collection | DOAJ |
| description | The SOX18 transcription factor plays an important role in endothelial cell specification, angiogenesis and atherogenesis. By profiling transcription factor interactions (TranSignal TM TF Protein Array) we identified several transcription factors implicated in angiogenesis that have the ability to bind to the SOX18 optimal promoter region in vitro. In this report we focused our attention on distinct transcription factors identified by the array as belonging to AP-1 and CREB/ATF protein families. In particular, we analyzed the effects of CREB, JunB, c-Jun and ATF3 on SOX18 gene expression. Functional analysis revealed that CREB acts as a repressor, while JunB, c-Jun and ATF3 act as activators of SOX18 promoter activity. Our findings indicate that a transcriptional network that includes CREB, JunB, c-Jun and ATF3 could be involved in angiogenesis-related transcriptional regulation of the SOX18 gene. |
| first_indexed | 2024-12-16T14:41:30Z |
| format | Article |
| id | doaj.art-43664d0a150a4ea9ab26cc8970b5f8eb |
| institution | Directory Open Access Journal |
| issn | 0354-4664 |
| language | English |
| last_indexed | 2024-12-16T14:41:30Z |
| publishDate | 2011-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-43664d0a150a4ea9ab26cc8970b5f8eb2022-12-21T22:27:53ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642011-01-0163351752510.2298/ABS1103517PMembers of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expressionPetrović IsidoraKovačević-Grujičić NatašaPopović JelenaKrstić A.Milivojević MilenaStevanović MilenaThe SOX18 transcription factor plays an important role in endothelial cell specification, angiogenesis and atherogenesis. By profiling transcription factor interactions (TranSignal TM TF Protein Array) we identified several transcription factors implicated in angiogenesis that have the ability to bind to the SOX18 optimal promoter region in vitro. In this report we focused our attention on distinct transcription factors identified by the array as belonging to AP-1 and CREB/ATF protein families. In particular, we analyzed the effects of CREB, JunB, c-Jun and ATF3 on SOX18 gene expression. Functional analysis revealed that CREB acts as a repressor, while JunB, c-Jun and ATF3 act as activators of SOX18 promoter activity. Our findings indicate that a transcriptional network that includes CREB, JunB, c-Jun and ATF3 could be involved in angiogenesis-related transcriptional regulation of the SOX18 gene.http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641103517P.pdfSOX18CREB/ATFAP-1angiogenesis |
| spellingShingle | Petrović Isidora Kovačević-Grujičić Nataša Popović Jelena Krstić A. Milivojević Milena Stevanović Milena Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression Archives of Biological Sciences SOX18 CREB/ATF AP-1 angiogenesis |
| title | Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression |
| title_full | Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression |
| title_fullStr | Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression |
| title_full_unstemmed | Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression |
| title_short | Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression |
| title_sort | members of the creb atf and ap1 family of transcription factors are involved in the regulation of sox18 gene expression |
| topic | SOX18 CREB/ATF AP-1 angiogenesis |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641103517P.pdf |
| work_keys_str_mv | AT petrovicisidora membersofthecrebatfandap1familyoftranscriptionfactorsareinvolvedintheregulationofsox18geneexpression AT kovacevicgrujicicnatasa membersofthecrebatfandap1familyoftranscriptionfactorsareinvolvedintheregulationofsox18geneexpression AT popovicjelena membersofthecrebatfandap1familyoftranscriptionfactorsareinvolvedintheregulationofsox18geneexpression AT krstica membersofthecrebatfandap1familyoftranscriptionfactorsareinvolvedintheregulationofsox18geneexpression AT milivojevicmilena membersofthecrebatfandap1familyoftranscriptionfactorsareinvolvedintheregulationofsox18geneexpression AT stevanovicmilena membersofthecrebatfandap1familyoftranscriptionfactorsareinvolvedintheregulationofsox18geneexpression |