Relationship between Helicobacter pylori infection and white matter lesions in patients with migraine
Abstract Background/aim White matter lesions (WML) are more frequently observed in migraine patients than in the average population. Associations between Helicobacter pylori (H. pylori) infection and different extraintestinal pathologies have been identified. Here, we aimed to investigate the associ...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-022-02715-0 |
| _version_ | 1811250960280846336 |
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| author | Serkan Öcal Ruhsen Öcal Nuretdin Suna |
| author_facet | Serkan Öcal Ruhsen Öcal Nuretdin Suna |
| author_sort | Serkan Öcal |
| collection | DOAJ |
| description | Abstract Background/aim White matter lesions (WML) are more frequently observed in migraine patients than in the average population. Associations between Helicobacter pylori (H. pylori) infection and different extraintestinal pathologies have been identified. Here, we aimed to investigate the association between H. pylori infection and WML in patients diagnosed with episodic migraine. Materials and methods A retrospective study was conducted with 526 subjects with a diagnosis of episodic migraine. Hyperintensity of WML had been previously evaluated in these patients with brain magnetic resonance imaging (MRI) examinations. Previous endoscopic gastric biopsy histopathological examination of the same patients and reports on H. pylori findings were recorded. The demographic characteristics of the patients, such as age, gender and chronic systemic diseases such as hypertension and diabetes mellitus (DM) were recorded. Statistical evaluation was made. Results Evaluation was made among 526 migraine patients who met the inclusion criteria, comprising 397 (75.5%) females and 129 (24.5%) males with a mean age of 45.57 ± 13.46 years (range, 18–69 years). WML was detected on brain MRI in 178 (33.8%) patients who were also positive for H. pylori (p < 0.05). Subjects who are H. pylori-positive with migraine, WML were observed at a 2.5-fold higher incidence on brain MRI (odds ratio: 2.562, 95% CI 1.784–3.680). WML was found to be more significant in patients with hypertension and migraine than those without (p < 0.001). Older age was also found to be associated with WML (OR = 1.07, 95% CI: 0.01–0.04, p < 0.001). The age (p < 0.001), H. pylori (p < 0.001), hypertension (p < 0.001), and hypertension + DM (p < 0.05), had significant associations in predicting WML according to the multivariate logistic regression analysis. The presence of hypertension had a higher odds ratio value than the other variables. Conclusion It was concluded that H. pylori infection, as a chronic infection, can be considered a risk factor in developing WML in subjects with migraine. |
| first_indexed | 2024-04-12T16:12:31Z |
| format | Article |
| id | doaj.art-4366a1ecb6f04de6b0480ed03c17098d |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-12T16:12:31Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-4366a1ecb6f04de6b0480ed03c17098d2022-12-22T03:25:51ZengBMCBMC Neurology1471-23772022-05-012211810.1186/s12883-022-02715-0Relationship between Helicobacter pylori infection and white matter lesions in patients with migraineSerkan Öcal0Ruhsen Öcal1Nuretdin Suna2Department of Gastroenterology, University of Health Sciences Antalya Training and Research HospitalAntalya Training and Research Hospital Department of NeurologyDepartment of Gastroenterology, Faculty of Medicine, Başkent UniversityAbstract Background/aim White matter lesions (WML) are more frequently observed in migraine patients than in the average population. Associations between Helicobacter pylori (H. pylori) infection and different extraintestinal pathologies have been identified. Here, we aimed to investigate the association between H. pylori infection and WML in patients diagnosed with episodic migraine. Materials and methods A retrospective study was conducted with 526 subjects with a diagnosis of episodic migraine. Hyperintensity of WML had been previously evaluated in these patients with brain magnetic resonance imaging (MRI) examinations. Previous endoscopic gastric biopsy histopathological examination of the same patients and reports on H. pylori findings were recorded. The demographic characteristics of the patients, such as age, gender and chronic systemic diseases such as hypertension and diabetes mellitus (DM) were recorded. Statistical evaluation was made. Results Evaluation was made among 526 migraine patients who met the inclusion criteria, comprising 397 (75.5%) females and 129 (24.5%) males with a mean age of 45.57 ± 13.46 years (range, 18–69 years). WML was detected on brain MRI in 178 (33.8%) patients who were also positive for H. pylori (p < 0.05). Subjects who are H. pylori-positive with migraine, WML were observed at a 2.5-fold higher incidence on brain MRI (odds ratio: 2.562, 95% CI 1.784–3.680). WML was found to be more significant in patients with hypertension and migraine than those without (p < 0.001). Older age was also found to be associated with WML (OR = 1.07, 95% CI: 0.01–0.04, p < 0.001). The age (p < 0.001), H. pylori (p < 0.001), hypertension (p < 0.001), and hypertension + DM (p < 0.05), had significant associations in predicting WML according to the multivariate logistic regression analysis. The presence of hypertension had a higher odds ratio value than the other variables. Conclusion It was concluded that H. pylori infection, as a chronic infection, can be considered a risk factor in developing WML in subjects with migraine.https://doi.org/10.1186/s12883-022-02715-0Helicobacter pyloriMigraineWhite matter lesions |
| spellingShingle | Serkan Öcal Ruhsen Öcal Nuretdin Suna Relationship between Helicobacter pylori infection and white matter lesions in patients with migraine BMC Neurology Helicobacter pylori Migraine White matter lesions |
| title | Relationship between Helicobacter pylori infection and white matter lesions in patients with migraine |
| title_full | Relationship between Helicobacter pylori infection and white matter lesions in patients with migraine |
| title_fullStr | Relationship between Helicobacter pylori infection and white matter lesions in patients with migraine |
| title_full_unstemmed | Relationship between Helicobacter pylori infection and white matter lesions in patients with migraine |
| title_short | Relationship between Helicobacter pylori infection and white matter lesions in patients with migraine |
| title_sort | relationship between helicobacter pylori infection and white matter lesions in patients with migraine |
| topic | Helicobacter pylori Migraine White matter lesions |
| url | https://doi.org/10.1186/s12883-022-02715-0 |
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