Early antibiotic exposure and development of asthma and allergic rhinitis in childhood
Abstract Background The prevalence of pediatric allergic diseases has increased rapidly in the United States over the past few decades. Recent studies suggest an association between the increase in allergic disease and early disturbances to the gut microbiome. The gut microbiome is a set of intestin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | BMC Pediatrics |
| Online Access: | http://link.springer.com/article/10.1186/s12887-019-1594-4 |
| _version_ | 1819033266585337856 |
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| author | Jeffrey Ni Hannah Friedman Bridget C. Boyd Andrew McGurn Piotr Babinski Talar Markossian Lara R. Dugas |
| author_facet | Jeffrey Ni Hannah Friedman Bridget C. Boyd Andrew McGurn Piotr Babinski Talar Markossian Lara R. Dugas |
| author_sort | Jeffrey Ni |
| collection | DOAJ |
| description | Abstract Background The prevalence of pediatric allergic diseases has increased rapidly in the United States over the past few decades. Recent studies suggest an association between the increase in allergic disease and early disturbances to the gut microbiome. The gut microbiome is a set of intestinal microorganisms that begins to form during birth and is highly susceptible to disturbance during the first year of life. Early antibiotic exposure may negatively impact the gut microbiota by altering the bacterial composition and causing dysbiosis, thus increasing the risk for developing childhood allergic disease. Methods We performed a retrospective chart review of data in Loyola University Medical Center’s (LUMC) Epic system from 2007 to 2016. We defined antibiotic exposure as orders in both the outpatient and inpatient settings. Inclusion criteria were being born at LUMC with at least two follow up visits. Asthma and allergic rhinitis diagnoses were obtained using ICD 9 and ICD 10 codes. We controlled for multiple confounding factors. Using Stata, bivariate logistic regression was performed between antibiotics from 0 to 12 months of life and development of disease. This analysis was repeated for total lifetime antibiotics. We defined statistically significant as p < .05. Results The administration of antibiotics within the first 12 months of life was significantly associated with lifetime asthma (OR 2.66; C. I 1.11–6.40) but not allergic rhinitis. There was a significant association between lifetime antibiotics and asthma (OR 3.54; C. I 1.99–6.30) and allergic rhinitis (OR 2.43; C. I 1.43–4.11). Conclusion Antibiotic administration in the first year of life and throughout lifetime is significantly associated with developing asthma and allergic rhinitis. These results provide support for a conservative approach regarding antibiotic use in early childhood. |
| first_indexed | 2024-12-21T07:15:07Z |
| format | Article |
| id | doaj.art-4368d24088954f76aba16c89a1473c2f |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-21T07:15:07Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-4368d24088954f76aba16c89a1473c2f2022-12-21T19:11:53ZengBMCBMC Pediatrics1471-24312019-07-011911810.1186/s12887-019-1594-4Early antibiotic exposure and development of asthma and allergic rhinitis in childhoodJeffrey Ni0Hannah Friedman1Bridget C. Boyd2Andrew McGurn3Piotr Babinski4Talar Markossian5Lara R. Dugas6Loyola University Medical CenterLoyola University Medical CenterLoyola University Medical CenterLoyola University Medical CenterLoyola University Medical CenterLoyola University Medical CenterLoyola University Medical CenterAbstract Background The prevalence of pediatric allergic diseases has increased rapidly in the United States over the past few decades. Recent studies suggest an association between the increase in allergic disease and early disturbances to the gut microbiome. The gut microbiome is a set of intestinal microorganisms that begins to form during birth and is highly susceptible to disturbance during the first year of life. Early antibiotic exposure may negatively impact the gut microbiota by altering the bacterial composition and causing dysbiosis, thus increasing the risk for developing childhood allergic disease. Methods We performed a retrospective chart review of data in Loyola University Medical Center’s (LUMC) Epic system from 2007 to 2016. We defined antibiotic exposure as orders in both the outpatient and inpatient settings. Inclusion criteria were being born at LUMC with at least two follow up visits. Asthma and allergic rhinitis diagnoses were obtained using ICD 9 and ICD 10 codes. We controlled for multiple confounding factors. Using Stata, bivariate logistic regression was performed between antibiotics from 0 to 12 months of life and development of disease. This analysis was repeated for total lifetime antibiotics. We defined statistically significant as p < .05. Results The administration of antibiotics within the first 12 months of life was significantly associated with lifetime asthma (OR 2.66; C. I 1.11–6.40) but not allergic rhinitis. There was a significant association between lifetime antibiotics and asthma (OR 3.54; C. I 1.99–6.30) and allergic rhinitis (OR 2.43; C. I 1.43–4.11). Conclusion Antibiotic administration in the first year of life and throughout lifetime is significantly associated with developing asthma and allergic rhinitis. These results provide support for a conservative approach regarding antibiotic use in early childhood.http://link.springer.com/article/10.1186/s12887-019-1594-4 |
| spellingShingle | Jeffrey Ni Hannah Friedman Bridget C. Boyd Andrew McGurn Piotr Babinski Talar Markossian Lara R. Dugas Early antibiotic exposure and development of asthma and allergic rhinitis in childhood BMC Pediatrics |
| title | Early antibiotic exposure and development of asthma and allergic rhinitis in childhood |
| title_full | Early antibiotic exposure and development of asthma and allergic rhinitis in childhood |
| title_fullStr | Early antibiotic exposure and development of asthma and allergic rhinitis in childhood |
| title_full_unstemmed | Early antibiotic exposure and development of asthma and allergic rhinitis in childhood |
| title_short | Early antibiotic exposure and development of asthma and allergic rhinitis in childhood |
| title_sort | early antibiotic exposure and development of asthma and allergic rhinitis in childhood |
| url | http://link.springer.com/article/10.1186/s12887-019-1594-4 |
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