Vitamin D and PTH: data from a cross-sectional study in an equatorial population
Objective: Investigate the prevalence of vitamin D deficiency in an equato rial population through a large-sample study. Methods: Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia – state of Pará), who had 25-hydroxy-vitami n D (25(OH)D) and intact pa...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2020-07-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/9/7/EC-20-0206.xml |
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| author | Natércia Neves Marques de Queiroz Franciane Trindade Cunha de Melo Fabrício de Souza Resende Luísa Corrêa Janaú Norberto Jorge Kzan de Souza Neto Manuela Nascimento de Lemos Ana Carolina Lobato Virgolino Maria Clara Neres Iunes de Oliveira Angélica Leite de Alcântara Lorena Vilhena de Moraes Tiago Franco David Wanderson Maia da Silva Scarlatt Souza Reis Márcia Costa dos Santos Ana Carolina Contente Braga de Souza Pedro Paulo Freire Piani Neyla Arroyo Lara Mourão Karem Mileo Felício João Felício Abrahão Neto João Soares Felício |
| author_facet | Natércia Neves Marques de Queiroz Franciane Trindade Cunha de Melo Fabrício de Souza Resende Luísa Corrêa Janaú Norberto Jorge Kzan de Souza Neto Manuela Nascimento de Lemos Ana Carolina Lobato Virgolino Maria Clara Neres Iunes de Oliveira Angélica Leite de Alcântara Lorena Vilhena de Moraes Tiago Franco David Wanderson Maia da Silva Scarlatt Souza Reis Márcia Costa dos Santos Ana Carolina Contente Braga de Souza Pedro Paulo Freire Piani Neyla Arroyo Lara Mourão Karem Mileo Felício João Felício Abrahão Neto João Soares Felício |
| author_sort | Natércia Neves Marques de Queiroz |
| collection | DOAJ |
| description | Objective: Investigate the prevalence of vitamin D deficiency in an equato rial population through a large-sample study.
Methods: Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia – state of Pará), who had 25-hydroxy-vitami n D (25(OH)D) and intact parathyroid hormone (PTH) serum levels measured by immunoassay method. Those with history of acute or chronic diseases were excluded. Abnorm al levels of calcium, creatinine, glycemia and albumin were also exclusion criteria.
Results: 25(OH)D levels were 29.1 ± 8.2 ng/mL and values <12.7 ng/mL we re equal to < −2 s.d. below average. Hypovitaminosis D was present in 10% of subject s according to the Institute of Medicine (values <20 ng/mL) and in 59%, in con sonance with Endocrine Society (values 20–30 ng/mL as insufficiency and <20 ng/mL as defi ciency) criteria. Individuals were divided according to four age brackets: childr en, adolescents, adults and elderly, and their 25(OH)D levels were: 33 ± 9; 28.5 ± 7.4; 28.3 ± 7.7; 29.3 ± 8.5 ng/mL, respectively. All groups differed in 25(OH)D, except adolescents vs adults. Regression model showed BMI, sex, living zone (urban or rural) and age as independent variables to 25(OH)D levels. Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20–30 ng/mL), a difference between P TH levels in these two groups was observed (95.9 ± 24.7 pg/mL vs 44.2 ± 64.5 pg/mL; P < 0.01). Additionally, the most accurate predictive vitamin D level for subclinical hy perparathyroidism in ROC curve was 26 ng/mL.
Conclusion: Our equatorial population showed low prevalence of vitamin D hypovitaminosis ranging with age bracket. The insufficient category by Endocrine Society was corroborated by our PTH data. |
| first_indexed | 2024-12-16T06:52:32Z |
| format | Article |
| id | doaj.art-4369c02f81174e1e99e010b1d56f4970 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-16T06:52:32Z |
| publishDate | 2020-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-4369c02f81174e1e99e010b1d56f49702022-12-21T22:40:21ZengBioscientificaEndocrine Connections2049-36142049-36142020-07-0197667675https://doi.org/10.1530/EC-20-0206Vitamin D and PTH: data from a cross-sectional study in an equatorial populationNatércia Neves Marques de Queiroz0Franciane Trindade Cunha de Melo1Fabrício de Souza Resende2Luísa Corrêa Janaú3Norberto Jorge Kzan de Souza Neto4Manuela Nascimento de Lemos5Ana Carolina Lobato Virgolino6Maria Clara Neres Iunes de Oliveira7Angélica Leite de Alcântara8Lorena Vilhena de Moraes9Tiago Franco David10Wanderson Maia da Silva11Scarlatt Souza Reis12Márcia Costa dos Santos13Ana Carolina Contente Braga de Souza14Pedro Paulo Freire Piani15Neyla Arroyo Lara Mourão16Karem Mileo Felício17João Felício Abrahão Neto18João Soares Felício19University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belem, Pará, BrazilObjective: Investigate the prevalence of vitamin D deficiency in an equato rial population through a large-sample study. Methods: Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia – state of Pará), who had 25-hydroxy-vitami n D (25(OH)D) and intact parathyroid hormone (PTH) serum levels measured by immunoassay method. Those with history of acute or chronic diseases were excluded. Abnorm al levels of calcium, creatinine, glycemia and albumin were also exclusion criteria. Results: 25(OH)D levels were 29.1 ± 8.2 ng/mL and values <12.7 ng/mL we re equal to < −2 s.d. below average. Hypovitaminosis D was present in 10% of subject s according to the Institute of Medicine (values <20 ng/mL) and in 59%, in con sonance with Endocrine Society (values 20–30 ng/mL as insufficiency and <20 ng/mL as defi ciency) criteria. Individuals were divided according to four age brackets: childr en, adolescents, adults and elderly, and their 25(OH)D levels were: 33 ± 9; 28.5 ± 7.4; 28.3 ± 7.7; 29.3 ± 8.5 ng/mL, respectively. All groups differed in 25(OH)D, except adolescents vs adults. Regression model showed BMI, sex, living zone (urban or rural) and age as independent variables to 25(OH)D levels. Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20–30 ng/mL), a difference between P TH levels in these two groups was observed (95.9 ± 24.7 pg/mL vs 44.2 ± 64.5 pg/mL; P < 0.01). Additionally, the most accurate predictive vitamin D level for subclinical hy perparathyroidism in ROC curve was 26 ng/mL. Conclusion: Our equatorial population showed low prevalence of vitamin D hypovitaminosis ranging with age bracket. The insufficient category by Endocrine Society was corroborated by our PTH data.https://ec.bioscientifica.com/view/journals/ec/9/7/EC-20-0206.xmlepidemiologyendocrinologyhypovitaminosis dvitamin d |
| spellingShingle | Natércia Neves Marques de Queiroz Franciane Trindade Cunha de Melo Fabrício de Souza Resende Luísa Corrêa Janaú Norberto Jorge Kzan de Souza Neto Manuela Nascimento de Lemos Ana Carolina Lobato Virgolino Maria Clara Neres Iunes de Oliveira Angélica Leite de Alcântara Lorena Vilhena de Moraes Tiago Franco David Wanderson Maia da Silva Scarlatt Souza Reis Márcia Costa dos Santos Ana Carolina Contente Braga de Souza Pedro Paulo Freire Piani Neyla Arroyo Lara Mourão Karem Mileo Felício João Felício Abrahão Neto João Soares Felício Vitamin D and PTH: data from a cross-sectional study in an equatorial population Endocrine Connections epidemiology endocrinology hypovitaminosis d vitamin d |
| title | Vitamin D and PTH: data from a cross-sectional study in an equatorial population |
| title_full | Vitamin D and PTH: data from a cross-sectional study in an equatorial population |
| title_fullStr | Vitamin D and PTH: data from a cross-sectional study in an equatorial population |
| title_full_unstemmed | Vitamin D and PTH: data from a cross-sectional study in an equatorial population |
| title_short | Vitamin D and PTH: data from a cross-sectional study in an equatorial population |
| title_sort | vitamin d and pth data from a cross sectional study in an equatorial population |
| topic | epidemiology endocrinology hypovitaminosis d vitamin d |
| url | https://ec.bioscientifica.com/view/journals/ec/9/7/EC-20-0206.xml |
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