Cynaropicrin: a comprehensive research review and therapeutic potential as an anti- hepatitis C virus agent
The different pharmacologic properties of plants-containing cynaropicrin, especially artichokes, have been known for many centuries. More recently, cynaropicrin exhibited a potential activity against all genotypes of hepatitis C virus (HCV). Cynaropicrin has also shown a wide range of other pharmaco...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00472/full |
| _version_ | 1819241263227994112 |
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| author | Mahmoud Fahmi Elsebai Andrei Mocan Atanas G. Atanasov Atanas G. Atanasov |
| author_facet | Mahmoud Fahmi Elsebai Andrei Mocan Atanas G. Atanasov Atanas G. Atanasov |
| author_sort | Mahmoud Fahmi Elsebai |
| collection | DOAJ |
| description | The different pharmacologic properties of plants-containing cynaropicrin, especially artichokes, have been known for many centuries. More recently, cynaropicrin exhibited a potential activity against all genotypes of hepatitis C virus (HCV). Cynaropicrin has also shown a wide range of other pharmacologic properties such as anti-hyperlipidemic, anti-trypanosomal, anti-malarial, antifeedant, antispasmodic, anti-photoaging, and anti-tumor action, as well as activation of bitter sensory receptors, and anti-inflammatory properties (e.g., associated with the suppression of the key pro-inflammatory NF-κB pathway). These pharmacological effects are very supportive factors to its outstanding activity against HCV. Structurally, cynaropicrin might be considered as a potential drug candidate, since it has no violations for the rule of five and its water-solubility could allow formulation as therapeutic injections. Moreover, cynaropicrin is a small molecule that can be easily synthesized and as the major constituent of the edible plant artichoke, which has a history of safe dietary use. In summary, cynaropicrin is a promising bioactive natural product that, with minor hit-to-lead optimization, might be developed as a drug for HCV. |
| first_indexed | 2024-12-23T14:21:08Z |
| format | Article |
| id | doaj.art-4369e22f09af47deabe430406184257b |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-23T14:21:08Z |
| publishDate | 2016-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4369e22f09af47deabe430406184257b2022-12-21T17:43:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122016-12-01710.3389/fphar.2016.00472231724Cynaropicrin: a comprehensive research review and therapeutic potential as an anti- hepatitis C virus agentMahmoud Fahmi Elsebai0Andrei Mocan1Atanas G. Atanasov2Atanas G. Atanasov3Department of Pharmacognosy, Faculty of Pharmacy, Mansoura UniversityDepartment of Pharmaceutical Botany, Iuliu Hațieganu University of Medicine and PharmacyUniversity of ViennaInstitute of Genetics and Animal Breeding of the Polish Academy of SciencesThe different pharmacologic properties of plants-containing cynaropicrin, especially artichokes, have been known for many centuries. More recently, cynaropicrin exhibited a potential activity against all genotypes of hepatitis C virus (HCV). Cynaropicrin has also shown a wide range of other pharmacologic properties such as anti-hyperlipidemic, anti-trypanosomal, anti-malarial, antifeedant, antispasmodic, anti-photoaging, and anti-tumor action, as well as activation of bitter sensory receptors, and anti-inflammatory properties (e.g., associated with the suppression of the key pro-inflammatory NF-κB pathway). These pharmacological effects are very supportive factors to its outstanding activity against HCV. Structurally, cynaropicrin might be considered as a potential drug candidate, since it has no violations for the rule of five and its water-solubility could allow formulation as therapeutic injections. Moreover, cynaropicrin is a small molecule that can be easily synthesized and as the major constituent of the edible plant artichoke, which has a history of safe dietary use. In summary, cynaropicrin is a promising bioactive natural product that, with minor hit-to-lead optimization, might be developed as a drug for HCV.http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00472/fullAntibacterialHepatitis C virusanti-inflammatoryantitumorAnti-hyperlipidemicAnti-parasite |
| spellingShingle | Mahmoud Fahmi Elsebai Andrei Mocan Atanas G. Atanasov Atanas G. Atanasov Cynaropicrin: a comprehensive research review and therapeutic potential as an anti- hepatitis C virus agent Frontiers in Pharmacology Antibacterial Hepatitis C virus anti-inflammatory antitumor Anti-hyperlipidemic Anti-parasite |
| title | Cynaropicrin: a comprehensive research review and therapeutic potential as an anti- hepatitis C virus agent |
| title_full | Cynaropicrin: a comprehensive research review and therapeutic potential as an anti- hepatitis C virus agent |
| title_fullStr | Cynaropicrin: a comprehensive research review and therapeutic potential as an anti- hepatitis C virus agent |
| title_full_unstemmed | Cynaropicrin: a comprehensive research review and therapeutic potential as an anti- hepatitis C virus agent |
| title_short | Cynaropicrin: a comprehensive research review and therapeutic potential as an anti- hepatitis C virus agent |
| title_sort | cynaropicrin a comprehensive research review and therapeutic potential as an anti hepatitis c virus agent |
| topic | Antibacterial Hepatitis C virus anti-inflammatory antitumor Anti-hyperlipidemic Anti-parasite |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00472/full |
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