A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsules
In this work, a new isocratic reverse phase chromatographic method was developed using HPLC for ziprasidone hydrochloride monohydrate (ZHM). The newly developed method is applicable for assay determination of the ZHM in capsule dosage form. The chromatographic separation of ZHM was achieved on a Zor...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610312001536 |
| _version_ | 1811284291735257088 |
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| author | Ruchi Bansal Karthikeyan Chandrabose N.S. Hari Narayana Moorthy Dhirendra Pratap Singh Digvijay Singh Piyush Trivedi |
| author_facet | Ruchi Bansal Karthikeyan Chandrabose N.S. Hari Narayana Moorthy Dhirendra Pratap Singh Digvijay Singh Piyush Trivedi |
| author_sort | Ruchi Bansal |
| collection | DOAJ |
| description | In this work, a new isocratic reverse phase chromatographic method was developed using HPLC for ziprasidone hydrochloride monohydrate (ZHM). The newly developed method is applicable for assay determination of the ZHM in capsule dosage form. The chromatographic separation of ZHM was achieved on a Zorbax SB C-8 (50 × 4.6) mm, 3.5 μm column within a short runtime of 2 min. The method was validated according to the International Conference on Harmonization (ICH) guidelines with respect to specificity, precision, linearity, accuracy, range, stability of analytical solution, robustness and system suitability. The satisfying recoveries (98–100%) and low coefficient of variation confirmed the suitability of the proposed method for the routine analysis of ZHM in pharmaceuticals. |
| first_indexed | 2024-04-13T02:26:26Z |
| format | Article |
| id | doaj.art-436a3db67b4049c5a036f56c81f866c3 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-04-13T02:26:26Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-436a3db67b4049c5a036f56c81f866c32022-12-22T03:06:45ZengElsevierJournal of Saudi Chemical Society1319-61032016-09-0120S1S161S16710.1016/j.jscs.2012.10.005A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsulesRuchi Bansal0Karthikeyan Chandrabose1N.S. Hari Narayana Moorthy2Dhirendra Pratap Singh3Digvijay Singh4Piyush Trivedi5Jubilant Organosys Ltd., Noida 201301, Uttar Pradesh, IndiaSchool of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal 462036, IndiaSchool of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal 462036, IndiaJubilant Organosys Ltd., Noida 201301, Uttar Pradesh, IndiaJubilant Organosys Ltd., Noida 201301, Uttar Pradesh, IndiaSchool of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal 462036, IndiaIn this work, a new isocratic reverse phase chromatographic method was developed using HPLC for ziprasidone hydrochloride monohydrate (ZHM). The newly developed method is applicable for assay determination of the ZHM in capsule dosage form. The chromatographic separation of ZHM was achieved on a Zorbax SB C-8 (50 × 4.6) mm, 3.5 μm column within a short runtime of 2 min. The method was validated according to the International Conference on Harmonization (ICH) guidelines with respect to specificity, precision, linearity, accuracy, range, stability of analytical solution, robustness and system suitability. The satisfying recoveries (98–100%) and low coefficient of variation confirmed the suitability of the proposed method for the routine analysis of ZHM in pharmaceuticals.http://www.sciencedirect.com/science/article/pii/S1319610312001536HPLCIsocraticZiprasidone hydrochloride monohydrateAssayValidationCapsule |
| spellingShingle | Ruchi Bansal Karthikeyan Chandrabose N.S. Hari Narayana Moorthy Dhirendra Pratap Singh Digvijay Singh Piyush Trivedi A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsules Journal of Saudi Chemical Society HPLC Isocratic Ziprasidone hydrochloride monohydrate Assay Validation Capsule |
| title | A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsules |
| title_full | A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsules |
| title_fullStr | A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsules |
| title_full_unstemmed | A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsules |
| title_short | A new simple and rapid validated RP-HPLC method for determination of ziprasidone in ziprasidone capsules |
| title_sort | new simple and rapid validated rp hplc method for determination of ziprasidone in ziprasidone capsules |
| topic | HPLC Isocratic Ziprasidone hydrochloride monohydrate Assay Validation Capsule |
| url | http://www.sciencedirect.com/science/article/pii/S1319610312001536 |
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