Design, Synthesis, and Biological Evaluation of Marine Lissodendrins B Analogues as Modulators of ABCB1-Mediated Multidrug Resistance

Design, Synthesis, and Biological Evaluation of Marine Lissodendrins B Analogues as Modulators of ABCB1-Mediated Multidrug Resistance

Multidrug resistance (MDR) caused by ATP-Binding Cassette Subfamily B Member 1 (ABCB1, P-glycoprotein, P-gp) is a major barrier for the success of chemotherapy in clinics. In this study, we designed and synthesized a total of 19 Lissodendrins B analogues and tested their ABCB1-mediated MDR reversal...

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Bibliographic Details
Main Authors: Chaoming Wang, Jinman Zhang, Xianfeng Wei, Mengke Yang, Weiping Ma, Rilei Yu, Ming Liu, Tao Jiang
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Marine Drugs
Subjects:
Lissodendrins B analogues
Y-shaped scaffold
tetrahydroisoquinoline
multidrug resistance
ABCB1 inhibitors
Online Access:https://www.mdpi.com/1660-3397/21/5/314

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