Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic intervention
Altered lipid metabolism is a well-recognized feature of solid cancers, including colorectal cancer. In colorectal cancer, upregulation of lipid metabolism contributes to initiation, progression, and metastasis; thus, aberrant lipid metabolism contributes to a poor patient outcome. The inactivating...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1343061/full |
| _version_ | 1797246714464174080 |
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| author | Courtney O. Kelson Yekaterina Y. Zaytseva Yekaterina Y. Zaytseva |
| author_facet | Courtney O. Kelson Yekaterina Y. Zaytseva Yekaterina Y. Zaytseva |
| author_sort | Courtney O. Kelson |
| collection | DOAJ |
| description | Altered lipid metabolism is a well-recognized feature of solid cancers, including colorectal cancer. In colorectal cancer, upregulation of lipid metabolism contributes to initiation, progression, and metastasis; thus, aberrant lipid metabolism contributes to a poor patient outcome. The inactivating mutation of APC, a vital tumor suppressor in the Wnt signaling pathway, is a key event that occurs early in the majority of colorectal cancer cases. The potential crosstalk between lipid metabolism and APC-driven colorectal cancer is poorly understood. This review collectively highlights and summarizes the limited understanding between mutations in APC and the upregulation of Wnt/beta-catenin signaling and lipid metabolism. The interconnection between APC inactivation and aberrant lipid metabolism activates Wnt/beta-catenin signaling which causes transcriptome, epigenetic, and microbiome changes to promote colorectal cancer initiation and progression. Furthermore, the downstream effects of this collaborative effort between aberrant Wnt/beta-catenin signaling and lipid metabolism are enhanced stemness, cellular proliferation, prooncogenic signaling, and survival. Understanding the mechanistic link between APC inactivation and alterations in lipid metabolism may foster identification of new therapeutic targets to enable development of more efficacious strategies for prevention and/or treatment of colorectal cancer. |
| first_indexed | 2024-04-24T19:47:11Z |
| format | Article |
| id | doaj.art-436be465f81d46b09dfbf1990f79ad7c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T19:47:11Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-436be465f81d46b09dfbf1990f79ad7c2024-03-25T04:58:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-03-011410.3389/fonc.2024.13430611343061Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic interventionCourtney O. Kelson0Yekaterina Y. Zaytseva1Yekaterina Y. Zaytseva2Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United StatesDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United StatesMarkey Cancer Center, University of Kentucky, Lexington, KY, United StatesAltered lipid metabolism is a well-recognized feature of solid cancers, including colorectal cancer. In colorectal cancer, upregulation of lipid metabolism contributes to initiation, progression, and metastasis; thus, aberrant lipid metabolism contributes to a poor patient outcome. The inactivating mutation of APC, a vital tumor suppressor in the Wnt signaling pathway, is a key event that occurs early in the majority of colorectal cancer cases. The potential crosstalk between lipid metabolism and APC-driven colorectal cancer is poorly understood. This review collectively highlights and summarizes the limited understanding between mutations in APC and the upregulation of Wnt/beta-catenin signaling and lipid metabolism. The interconnection between APC inactivation and aberrant lipid metabolism activates Wnt/beta-catenin signaling which causes transcriptome, epigenetic, and microbiome changes to promote colorectal cancer initiation and progression. Furthermore, the downstream effects of this collaborative effort between aberrant Wnt/beta-catenin signaling and lipid metabolism are enhanced stemness, cellular proliferation, prooncogenic signaling, and survival. Understanding the mechanistic link between APC inactivation and alterations in lipid metabolism may foster identification of new therapeutic targets to enable development of more efficacious strategies for prevention and/or treatment of colorectal cancer.https://www.frontiersin.org/articles/10.3389/fonc.2024.1343061/fullAPC geneAPC-mediated signalingcolorectal cancerlipidslipid metabolism |
| spellingShingle | Courtney O. Kelson Yekaterina Y. Zaytseva Yekaterina Y. Zaytseva Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic intervention Frontiers in Oncology APC gene APC-mediated signaling colorectal cancer lipids lipid metabolism |
| title | Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic intervention |
| title_full | Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic intervention |
| title_fullStr | Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic intervention |
| title_full_unstemmed | Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic intervention |
| title_short | Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic intervention |
| title_sort | altered lipid metabolism in apc driven colorectal cancer the potential for therapeutic intervention |
| topic | APC gene APC-mediated signaling colorectal cancer lipids lipid metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1343061/full |
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