In Vitro Evaluation of <i>Leuconostoc mesenteroides</i> Cell-Free-Supernatant GBUT-21 against SARS-CoV-2
The unprecedented health catastrophe derived from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 infection) met with a phenomenal scientific response across the globe. Worldwide, the scientific community was focused on finding a cure for the deadly disease. A wide range of research...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/10/1581 |
| _version_ | 1827647810208530432 |
|---|---|
| author | Othman R. Alzahrani Yousef M. Hawsawi Abdullah D. Alanazi Hanan E. Alatwi Irfan A. Rather |
| author_facet | Othman R. Alzahrani Yousef M. Hawsawi Abdullah D. Alanazi Hanan E. Alatwi Irfan A. Rather |
| author_sort | Othman R. Alzahrani |
| collection | DOAJ |
| description | The unprecedented health catastrophe derived from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 infection) met with a phenomenal scientific response across the globe. Worldwide, the scientific community was focused on finding a cure for the deadly disease. A wide range of research studies has consistently revealed the link between SARS-CoV-2 infection severity and abnormal gut microbiomes, suggesting its potential in developing novel therapeutic approaches. Probiotics have been extensively studied to promote health in human hosts and reestablish a balance in the dysbiotic gut microbiome; however, there is strong skepticism about their safety and efficacy. Consequently, the metabolic signatures of probiotics, often referred to as "postbiotics", could prove of paramount importance for adjuvant cures in patients with SARS-CoV-2. Postbiotics exhibit safety, enhanced shelf-life, and stability and, therefore, could be implemented in SARS-CoV-2 prophylactic strategies with no undue adverse side effects. The current study is a preliminary investigation of the antiviral properties of postbiotic metabolites derived from <i>Leuconostoc mesenteroides</i> GBUT-21. The study focuses on the potential biological role in inactivating SARS-CoV-2 and reducing related inflammatory pathways. |
| first_indexed | 2024-03-09T19:24:45Z |
| format | Article |
| id | doaj.art-436bfc63fde340b1b6f5b6a8f281ba09 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T19:24:45Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-436bfc63fde340b1b6f5b6a8f281ba092023-11-24T03:02:22ZengMDPI AGVaccines2076-393X2022-09-011010158110.3390/vaccines10101581In Vitro Evaluation of <i>Leuconostoc mesenteroides</i> Cell-Free-Supernatant GBUT-21 against SARS-CoV-2Othman R. Alzahrani0Yousef M. Hawsawi1Abdullah D. Alanazi2Hanan E. Alatwi3Irfan A. Rather4Department of Biology, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi ArabiaResearch Center, King Faisal Specialist Hospital and Research Center, Jeddah 21499, Saudi ArabiaDepartment of Biological Sciences, Faculty of Science and Humanities, Shaqra University, P.O. Box 1040, Ad-Dawadimi 11911, Saudi ArabiaDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaThe unprecedented health catastrophe derived from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2 infection) met with a phenomenal scientific response across the globe. Worldwide, the scientific community was focused on finding a cure for the deadly disease. A wide range of research studies has consistently revealed the link between SARS-CoV-2 infection severity and abnormal gut microbiomes, suggesting its potential in developing novel therapeutic approaches. Probiotics have been extensively studied to promote health in human hosts and reestablish a balance in the dysbiotic gut microbiome; however, there is strong skepticism about their safety and efficacy. Consequently, the metabolic signatures of probiotics, often referred to as "postbiotics", could prove of paramount importance for adjuvant cures in patients with SARS-CoV-2. Postbiotics exhibit safety, enhanced shelf-life, and stability and, therefore, could be implemented in SARS-CoV-2 prophylactic strategies with no undue adverse side effects. The current study is a preliminary investigation of the antiviral properties of postbiotic metabolites derived from <i>Leuconostoc mesenteroides</i> GBUT-21. The study focuses on the potential biological role in inactivating SARS-CoV-2 and reducing related inflammatory pathways.https://www.mdpi.com/2076-393X/10/10/1581SARS-CoV-2<i>Leuconostoc mesenteroides</i>probioticsviruslactic acid bacteria |
| spellingShingle | Othman R. Alzahrani Yousef M. Hawsawi Abdullah D. Alanazi Hanan E. Alatwi Irfan A. Rather In Vitro Evaluation of <i>Leuconostoc mesenteroides</i> Cell-Free-Supernatant GBUT-21 against SARS-CoV-2 Vaccines SARS-CoV-2 <i>Leuconostoc mesenteroides</i> probiotics virus lactic acid bacteria |
| title | In Vitro Evaluation of <i>Leuconostoc mesenteroides</i> Cell-Free-Supernatant GBUT-21 against SARS-CoV-2 |
| title_full | In Vitro Evaluation of <i>Leuconostoc mesenteroides</i> Cell-Free-Supernatant GBUT-21 against SARS-CoV-2 |
| title_fullStr | In Vitro Evaluation of <i>Leuconostoc mesenteroides</i> Cell-Free-Supernatant GBUT-21 against SARS-CoV-2 |
| title_full_unstemmed | In Vitro Evaluation of <i>Leuconostoc mesenteroides</i> Cell-Free-Supernatant GBUT-21 against SARS-CoV-2 |
| title_short | In Vitro Evaluation of <i>Leuconostoc mesenteroides</i> Cell-Free-Supernatant GBUT-21 against SARS-CoV-2 |
| title_sort | in vitro evaluation of i leuconostoc mesenteroides i cell free supernatant gbut 21 against sars cov 2 |
| topic | SARS-CoV-2 <i>Leuconostoc mesenteroides</i> probiotics virus lactic acid bacteria |
| url | https://www.mdpi.com/2076-393X/10/10/1581 |
| work_keys_str_mv | AT othmanralzahrani invitroevaluationofileuconostocmesenteroidesicellfreesupernatantgbut21againstsarscov2 AT yousefmhawsawi invitroevaluationofileuconostocmesenteroidesicellfreesupernatantgbut21againstsarscov2 AT abdullahdalanazi invitroevaluationofileuconostocmesenteroidesicellfreesupernatantgbut21againstsarscov2 AT hananealatwi invitroevaluationofileuconostocmesenteroidesicellfreesupernatantgbut21againstsarscov2 AT irfanarather invitroevaluationofileuconostocmesenteroidesicellfreesupernatantgbut21againstsarscov2 |