Vitamin D status and disability among patients with multiple sclerosis: a systematic review and meta-analysis <br />Running title: Vitamin D status and MS disability
Association between the serum vitamin D level and disability of patients with multiple sclerosis (MS) has been investigated during several researches. However, these studies reported different results. The current study aims to estimate the correlation between the concentrations of 25 (OH) vitamin D...
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| Format: | Article |
| Language: | English |
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AIMS Press
2021-02-01
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| Series: | AIMS Neuroscience |
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| Online Access: | http://www.aimspress.com/article/doi/10.3934/Neuroscience.2021013?viewType=HTML |
| _version_ | 1818650052742086656 |
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| author | Mahmood Moosazadeh Fatemeh Nabinezhad-Male Mahdi Afshari Mohammad Mehdi Nasehi Mohammad Shabani Motahareh Kheradmand Iraj Aghaei |
| author_facet | Mahmood Moosazadeh Fatemeh Nabinezhad-Male Mahdi Afshari Mohammad Mehdi Nasehi Mohammad Shabani Motahareh Kheradmand Iraj Aghaei |
| author_sort | Mahmood Moosazadeh |
| collection | DOAJ |
| description | Association between the serum vitamin D level and disability of patients with multiple sclerosis (MS) has been investigated during several researches. However, these studies reported different results. The current study aims to estimate the correlation between the concentrations of 25 (OH) vitamin D and the level of disability among MS patients. Using Mesh and non-Mesh terms related to MS, disability level and vitamin D, different data banks were searched. Required information was extracted from the selected eligible primary articles. Stata version 11 software was applied for combining the primary correlation coefficients using random effect model. The effect of MS type and patients' age was assessed using meta-regression models. Sensitivity analysis was performed to investigate the role of each primary study in the pooled estimate. Egger test was applied to find any publication bias. Of 14 eligible studies, the total correlation coefficient (95% confidence interval) between 25 (OH) vitamin D level and disability in both sexes as well as among female was estimated as of −0.29 (−0.40, −0.17) and −0.35 (−0.46, −0.24) respectively. Two articles carried out among male did not report significant results. Our meta-analysis showed a significant negative correlation between 25 (OH) vitamin D level and disability of MS patients so that the disability reduces with increasing the 25 (OH) vitamin D level. |
| first_indexed | 2024-12-17T01:44:05Z |
| format | Article |
| id | doaj.art-436d99ebb55b4b9b928efd750f8ce1d2 |
| institution | Directory Open Access Journal |
| issn | 2373-7972 |
| language | English |
| last_indexed | 2024-12-17T01:44:05Z |
| publishDate | 2021-02-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Neuroscience |
| spelling | doaj.art-436d99ebb55b4b9b928efd750f8ce1d22022-12-21T22:08:14ZengAIMS PressAIMS Neuroscience2373-79722021-02-018223925310.3934/Neuroscience.2021013Vitamin D status and disability among patients with multiple sclerosis: a systematic review and meta-analysis <br />Running title: Vitamin D status and MS disabilityMahmood Moosazadeh0Fatemeh Nabinezhad-Male1Mahdi Afshari 2Mohammad Mehdi Nasehi 3Mohammad Shabani 4Motahareh Kheradmand5Iraj Aghaei 61. Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran2. Mazandaran University of Medical Sciences, Sari, Iran3. Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran4. Pediatric Neurology Department, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran5. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran6. Health Science Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran7. Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, IranAssociation between the serum vitamin D level and disability of patients with multiple sclerosis (MS) has been investigated during several researches. However, these studies reported different results. The current study aims to estimate the correlation between the concentrations of 25 (OH) vitamin D and the level of disability among MS patients. Using Mesh and non-Mesh terms related to MS, disability level and vitamin D, different data banks were searched. Required information was extracted from the selected eligible primary articles. Stata version 11 software was applied for combining the primary correlation coefficients using random effect model. The effect of MS type and patients' age was assessed using meta-regression models. Sensitivity analysis was performed to investigate the role of each primary study in the pooled estimate. Egger test was applied to find any publication bias. Of 14 eligible studies, the total correlation coefficient (95% confidence interval) between 25 (OH) vitamin D level and disability in both sexes as well as among female was estimated as of −0.29 (−0.40, −0.17) and −0.35 (−0.46, −0.24) respectively. Two articles carried out among male did not report significant results. Our meta-analysis showed a significant negative correlation between 25 (OH) vitamin D level and disability of MS patients so that the disability reduces with increasing the 25 (OH) vitamin D level.http://www.aimspress.com/article/doi/10.3934/Neuroscience.2021013?viewType=HTMLmultiple sclerosismsdisabilityvitamin dmeta-analysis |
| spellingShingle | Mahmood Moosazadeh Fatemeh Nabinezhad-Male Mahdi Afshari Mohammad Mehdi Nasehi Mohammad Shabani Motahareh Kheradmand Iraj Aghaei Vitamin D status and disability among patients with multiple sclerosis: a systematic review and meta-analysis <br />Running title: Vitamin D status and MS disability AIMS Neuroscience multiple sclerosis ms disability vitamin d meta-analysis |
| title | Vitamin D status and disability among patients with multiple sclerosis: a systematic review and meta-analysis <br />Running title: Vitamin D status and MS disability |
| title_full | Vitamin D status and disability among patients with multiple sclerosis: a systematic review and meta-analysis <br />Running title: Vitamin D status and MS disability |
| title_fullStr | Vitamin D status and disability among patients with multiple sclerosis: a systematic review and meta-analysis <br />Running title: Vitamin D status and MS disability |
| title_full_unstemmed | Vitamin D status and disability among patients with multiple sclerosis: a systematic review and meta-analysis <br />Running title: Vitamin D status and MS disability |
| title_short | Vitamin D status and disability among patients with multiple sclerosis: a systematic review and meta-analysis <br />Running title: Vitamin D status and MS disability |
| title_sort | vitamin d status and disability among patients with multiple sclerosis a systematic review and meta analysis br running title vitamin d status and ms disability |
| topic | multiple sclerosis ms disability vitamin d meta-analysis |
| url | http://www.aimspress.com/article/doi/10.3934/Neuroscience.2021013?viewType=HTML |
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