Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla
One new benzofuran, (2R)-(2',4'-dihydroxybenzyl)-6,7-methylenedioxy-2,3-dihydrobenzofuran (1), one new phenylisocoumarin, 3-(2'-hydroxyphenyl)-6,8-dihydroxy-7-methoxy-isocoumarin (2), and one new benzofuroisocoumarin, platyphyllarin C (3), were isolated from the ethanolic extract of L...
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MDPI AG
2015-04-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/4/6844 |
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| author | Yu-Chi Tsai Chia-Chun Hsu Mohamed El-Shazly Shang-Yu Chiang Chau-Chung Wu Chin-Chung Wu Wan-Chun Lai Ming-Hong Yen Yang-Chang Wu Fang-Rong Chang |
| author_facet | Yu-Chi Tsai Chia-Chun Hsu Mohamed El-Shazly Shang-Yu Chiang Chau-Chung Wu Chin-Chung Wu Wan-Chun Lai Ming-Hong Yen Yang-Chang Wu Fang-Rong Chang |
| author_sort | Yu-Chi Tsai |
| collection | DOAJ |
| description | One new benzofuran, (2R)-(2',4'-dihydroxybenzyl)-6,7-methylenedioxy-2,3-dihydrobenzofuran (1), one new phenylisocoumarin, 3-(2'-hydroxyphenyl)-6,8-dihydroxy-7-methoxy-isocoumarin (2), and one new benzofuroisocoumarin, platyphyllarin C (3), were isolated from the ethanolic extract of Liriope platyphylla aerial parts, along with seventeen known compounds. The structures of the isolates were established by spectroscopic analysis and comparison with the literature data. The results indicated that structures 1–3 are uncommon in Nature. Benzofuroisocoumarin 4, flavonoids 9, 10, and 13–15, and homoisoflavonoids 19 and 20 exhibited significant binding activity to estrogen-receptor α and/or β as demonstrated by the SEAP reporter assay system in an MCF-7 cell-line. |
| first_indexed | 2024-12-22T02:14:32Z |
| format | Article |
| id | doaj.art-436e2d6709874cfdb6f7ec97ef4765c3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T02:14:32Z |
| publishDate | 2015-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-436e2d6709874cfdb6f7ec97ef4765c32022-12-21T18:42:18ZengMDPI AGMolecules1420-30492015-04-012046844685510.3390/molecules20046844molecules20046844Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphyllaYu-Chi Tsai0Chia-Chun Hsu1Mohamed El-Shazly2Shang-Yu Chiang3Chau-Chung Wu4Chin-Chung Wu5Wan-Chun Lai6Ming-Hong Yen7Yang-Chang Wu8Fang-Rong Chang9Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, TaiwanOne new benzofuran, (2R)-(2',4'-dihydroxybenzyl)-6,7-methylenedioxy-2,3-dihydrobenzofuran (1), one new phenylisocoumarin, 3-(2'-hydroxyphenyl)-6,8-dihydroxy-7-methoxy-isocoumarin (2), and one new benzofuroisocoumarin, platyphyllarin C (3), were isolated from the ethanolic extract of Liriope platyphylla aerial parts, along with seventeen known compounds. The structures of the isolates were established by spectroscopic analysis and comparison with the literature data. The results indicated that structures 1–3 are uncommon in Nature. Benzofuroisocoumarin 4, flavonoids 9, 10, and 13–15, and homoisoflavonoids 19 and 20 exhibited significant binding activity to estrogen-receptor α and/or β as demonstrated by the SEAP reporter assay system in an MCF-7 cell-line.http://www.mdpi.com/1420-3049/20/4/6844LiliaceaeLiriope platyphyllabenzofuroisocoumarinhomoisoflavonoidestrogenic activityestrogen-receptor agonist |
| spellingShingle | Yu-Chi Tsai Chia-Chun Hsu Mohamed El-Shazly Shang-Yu Chiang Chau-Chung Wu Chin-Chung Wu Wan-Chun Lai Ming-Hong Yen Yang-Chang Wu Fang-Rong Chang Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla Molecules Liliaceae Liriope platyphylla benzofuroisocoumarin homoisoflavonoid estrogenic activity estrogen-receptor agonist |
| title | Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla |
| title_full | Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla |
| title_fullStr | Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla |
| title_full_unstemmed | Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla |
| title_short | Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla |
| title_sort | phytochemicals and estrogen receptor agonists from the aerial parts of liriope platyphylla |
| topic | Liliaceae Liriope platyphylla benzofuroisocoumarin homoisoflavonoid estrogenic activity estrogen-receptor agonist |
| url | http://www.mdpi.com/1420-3049/20/4/6844 |
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