The Key Role of Exosomes on the Pre-metastatic Niche Formation in Tumors
Exosomes or other extracellular vesicles released from cells play an important role in cell-to-cell communication by transferring bio-information (DNA, coding/non-coding RNA, and proteins), which indicates parental cell status to recipient cells in the extracellular environment. Increasingly, eviden...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.703640/full |
| _version_ | 1818358740811776000 |
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| author | Xuyang Yang Yang Zhang Yaguang Zhang Su Zhang Lei Qiu Zixuan Zhuang Mingtian Wei Xiangbing Deng Ziqiang Wang Junhong Han |
| author_facet | Xuyang Yang Yang Zhang Yaguang Zhang Su Zhang Lei Qiu Zixuan Zhuang Mingtian Wei Xiangbing Deng Ziqiang Wang Junhong Han |
| author_sort | Xuyang Yang |
| collection | DOAJ |
| description | Exosomes or other extracellular vesicles released from cells play an important role in cell-to-cell communication by transferring bio-information (DNA, coding/non-coding RNA, and proteins), which indicates parental cell status to recipient cells in the extracellular environment. Increasingly, evidence shows that tumor-derived exosomes mediate tumor pre-metastatic niche (PMN) remodeling to establish a supportive and receptive niche to promote tumor cell colonization and metastasis. Uptake of genetic information by target cells in the extracellular environment triggers epigenetic changes that contribute to PMN formation. Here, we provide a comprehensive overview of the current understanding of exosomes-mediated reprogramming of cells in PMN formation. |
| first_indexed | 2024-12-13T20:33:49Z |
| format | Article |
| id | doaj.art-436ea58c7c4e418bbaafdd73a0b1fa93 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-13T20:33:49Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-436ea58c7c4e418bbaafdd73a0b1fa932022-12-21T23:32:21ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-09-01810.3389/fmolb.2021.703640703640The Key Role of Exosomes on the Pre-metastatic Niche Formation in TumorsXuyang Yang0Yang Zhang1Yaguang Zhang2Su Zhang3Lei Qiu4Zixuan Zhuang5Mingtian Wei6Xiangbing Deng7Ziqiang Wang8Junhong Han9State Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaExosomes or other extracellular vesicles released from cells play an important role in cell-to-cell communication by transferring bio-information (DNA, coding/non-coding RNA, and proteins), which indicates parental cell status to recipient cells in the extracellular environment. Increasingly, evidence shows that tumor-derived exosomes mediate tumor pre-metastatic niche (PMN) remodeling to establish a supportive and receptive niche to promote tumor cell colonization and metastasis. Uptake of genetic information by target cells in the extracellular environment triggers epigenetic changes that contribute to PMN formation. Here, we provide a comprehensive overview of the current understanding of exosomes-mediated reprogramming of cells in PMN formation.https://www.frontiersin.org/articles/10.3389/fmolb.2021.703640/fullexosomes (EX)pre-metastastic nichetumormetastaseextracellular environment |
| spellingShingle | Xuyang Yang Yang Zhang Yaguang Zhang Su Zhang Lei Qiu Zixuan Zhuang Mingtian Wei Xiangbing Deng Ziqiang Wang Junhong Han The Key Role of Exosomes on the Pre-metastatic Niche Formation in Tumors Frontiers in Molecular Biosciences exosomes (EX) pre-metastastic niche tumor metastase extracellular environment |
| title | The Key Role of Exosomes on the Pre-metastatic Niche Formation in Tumors |
| title_full | The Key Role of Exosomes on the Pre-metastatic Niche Formation in Tumors |
| title_fullStr | The Key Role of Exosomes on the Pre-metastatic Niche Formation in Tumors |
| title_full_unstemmed | The Key Role of Exosomes on the Pre-metastatic Niche Formation in Tumors |
| title_short | The Key Role of Exosomes on the Pre-metastatic Niche Formation in Tumors |
| title_sort | key role of exosomes on the pre metastatic niche formation in tumors |
| topic | exosomes (EX) pre-metastastic niche tumor metastase extracellular environment |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.703640/full |
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