Copper chelation reduces early collagen deposition and preserves saliva secretion in irradiated salivary glands

Copper chelation reduces early collagen deposition and preserves saliva secretion in irradiated salivary glands

Radiation therapy is a first-line treatment for head and neck cancer; however, it typically leads to hyposalivation stemming from fibrosis of the salivary gland. Current strategies to restore glandular function are dependent on the presence of residual functional salivary gland tissue, a condition c...

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Bibliographic Details
Main Authors: Kihoon Nam, Harim Tavares Dos Santos, Frank M. Maslow, Travis Small, Vinit Shanbhag, Michael J. Petris, Olga J. Baker
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Head and neck cancer
Radiation therapy
Hyposalivation
Copper chelator
Drug delivery
Fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024003992

Internet

http://www.sciencedirect.com/science/article/pii/S2405844024003992

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