MRI-measured periprostatic adipose tissue volume as a prognostic predictor in prostate cancer patients undergoing laparoscopic radical prostatectomy
ABSTRACTIn this study, we evaluated the association between the PPAT volume and the prognosis of PCa patients after LRP. We retrospectively analysed data of 189 PCa patients who underwent LRP in Beijing Chaoyang Hospital. Volumes of PPAT and prostate were measured by magnetic resonance imaging (MRI)...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Adipocyte |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21623945.2023.2201964 |
| _version_ | 1827380596353007616 |
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| author | Tianyu Xiong Fang Cao Guangyi Zhu Xiaobo Ye Yun Cui Nianzeng Xing Huibo Zhang Yinong Niu |
| author_facet | Tianyu Xiong Fang Cao Guangyi Zhu Xiaobo Ye Yun Cui Nianzeng Xing Huibo Zhang Yinong Niu |
| author_sort | Tianyu Xiong |
| collection | DOAJ |
| description | ABSTRACTIn this study, we evaluated the association between the PPAT volume and the prognosis of PCa patients after LRP. We retrospectively analysed data of 189 PCa patients who underwent LRP in Beijing Chaoyang Hospital. Volumes of PPAT and prostate were measured by magnetic resonance imaging (MRI), and normalized PPAT volume was computed (PPAT volume divided by prostate volume). Patients were then stratified into the high-PPAT group (n = 95) and low-PPAT group (n = 94) by the median of normalized PPAT volume (73%). The high-PPAT group had significantly higher Gleason score (total score 8 or more, 39.0% vs. 4.3%, p < 0.001) and pathological stage (stage T3b, 28.4% vs. 13.8%, p = 0.048). No significant correlation between normalized PPAT volume and body mass index (ρ = −0.012, p = 0.872) was observed. Kaplan-Meier curve analysis showed the high-PPAT group had significantly shorter biochemical recurrence (BCR) interval (median progression-free survival time 15.9 months vs. 32.7 months, p = 0.001). Univiarate and multivariate Cox regression analyses showed high normalized PPAT volume (>73%) (hazard ratio 1.787 [1.075–3.156], p = 0.002) were independent risk factors for BCR post-operatively. In conclusion, MRI-measured PPAT volume is of significant prognostic value for PCa patients undergoing LRP. |
| first_indexed | 2024-03-08T13:37:16Z |
| format | Article |
| id | doaj.art-437227b81c09476fafa1ee79031ff7dd |
| institution | Directory Open Access Journal |
| issn | 2162-3945 2162-397X |
| language | English |
| last_indexed | 2024-03-08T13:37:16Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Adipocyte |
| spelling | doaj.art-437227b81c09476fafa1ee79031ff7dd2024-01-16T15:50:36ZengTaylor & Francis GroupAdipocyte2162-39452162-397X2023-12-0112110.1080/21623945.2023.2201964MRI-measured periprostatic adipose tissue volume as a prognostic predictor in prostate cancer patients undergoing laparoscopic radical prostatectomyTianyu Xiong0Fang Cao1Guangyi Zhu2Xiaobo Ye3Yun Cui4Nianzeng Xing5Huibo Zhang6Yinong Niu7Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Cancer Hospital Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaABSTRACTIn this study, we evaluated the association between the PPAT volume and the prognosis of PCa patients after LRP. We retrospectively analysed data of 189 PCa patients who underwent LRP in Beijing Chaoyang Hospital. Volumes of PPAT and prostate were measured by magnetic resonance imaging (MRI), and normalized PPAT volume was computed (PPAT volume divided by prostate volume). Patients were then stratified into the high-PPAT group (n = 95) and low-PPAT group (n = 94) by the median of normalized PPAT volume (73%). The high-PPAT group had significantly higher Gleason score (total score 8 or more, 39.0% vs. 4.3%, p < 0.001) and pathological stage (stage T3b, 28.4% vs. 13.8%, p = 0.048). No significant correlation between normalized PPAT volume and body mass index (ρ = −0.012, p = 0.872) was observed. Kaplan-Meier curve analysis showed the high-PPAT group had significantly shorter biochemical recurrence (BCR) interval (median progression-free survival time 15.9 months vs. 32.7 months, p = 0.001). Univiarate and multivariate Cox regression analyses showed high normalized PPAT volume (>73%) (hazard ratio 1.787 [1.075–3.156], p = 0.002) were independent risk factors for BCR post-operatively. In conclusion, MRI-measured PPAT volume is of significant prognostic value for PCa patients undergoing LRP.https://www.tandfonline.com/doi/10.1080/21623945.2023.2201964Adipose tissuemagnetic resonance imagingprostate cancerlaparoscopic radical prostatectomybiochemical recurrence |
| spellingShingle | Tianyu Xiong Fang Cao Guangyi Zhu Xiaobo Ye Yun Cui Nianzeng Xing Huibo Zhang Yinong Niu MRI-measured periprostatic adipose tissue volume as a prognostic predictor in prostate cancer patients undergoing laparoscopic radical prostatectomy Adipocyte Adipose tissue magnetic resonance imaging prostate cancer laparoscopic radical prostatectomy biochemical recurrence |
| title | MRI-measured periprostatic adipose tissue volume as a prognostic predictor in prostate cancer patients undergoing laparoscopic radical prostatectomy |
| title_full | MRI-measured periprostatic adipose tissue volume as a prognostic predictor in prostate cancer patients undergoing laparoscopic radical prostatectomy |
| title_fullStr | MRI-measured periprostatic adipose tissue volume as a prognostic predictor in prostate cancer patients undergoing laparoscopic radical prostatectomy |
| title_full_unstemmed | MRI-measured periprostatic adipose tissue volume as a prognostic predictor in prostate cancer patients undergoing laparoscopic radical prostatectomy |
| title_short | MRI-measured periprostatic adipose tissue volume as a prognostic predictor in prostate cancer patients undergoing laparoscopic radical prostatectomy |
| title_sort | mri measured periprostatic adipose tissue volume as a prognostic predictor in prostate cancer patients undergoing laparoscopic radical prostatectomy |
| topic | Adipose tissue magnetic resonance imaging prostate cancer laparoscopic radical prostatectomy biochemical recurrence |
| url | https://www.tandfonline.com/doi/10.1080/21623945.2023.2201964 |
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