Mitragynine (Kratom)-Induced Cognitive Impairments in Mice Resemble Δ9-THC and Morphine Effects: Reversal by Cannabinoid CB1 Receptor Antagonism

Mitragynine (Kratom)-Induced Cognitive Impairments in Mice Resemble Δ9-THC and Morphine Effects: Reversal by Cannabinoid CB1 Receptor Antagonism

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Kratom is a widely abused plant-based drug preparation with a global interest in recent years, well beyond its native grounds in Southeast Asia. Mitragynine, its major psychoactive constituent is known to exhibit opioid-like behavioral effects with resultant neuroplasticity in the brain reward syste...

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Dades bibliogràfiques
Autors principals: Ismail Nurul Iman, Nur Aimi Zawami Ahmad, Nurul Aiman Mohd Yusof, Ummi Nasrah Talib, Anwar Norazit, Jaya Kumar, Muhammad Zulfadli Mehat, Zurina Hassan, Christian P. Müller, Mustapha Muzaimi
Format: Article
Idioma:English
Publicat: Frontiers Media S.A. 2021-09-01
Col·lecció:Frontiers in Pharmacology
Matèries:
kratom
mitragynine
morphine
Δ9-tetrahydrocannabinol (THC)
cannabinoid receptor 1 (CB1)
cognition
Accés en línia:https://www.frontiersin.org/articles/10.3389/fphar.2021.708055/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.708055/full

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