Efficient Oxidative Resolution of 1-Phenylphosphol-2-Ene and Diels–Alder Synthesis of Enantiopure Bicyclic and Tricyclic P-Stereogenic C-P Heterocycles

Efficient Oxidative Resolution of 1-Phenylphosphol-2-Ene and Diels–Alder Synthesis of Enantiopure Bicyclic and Tricyclic P-Stereogenic C-P Heterocycles

1-Phenylphosphol-2-ene 1-oxide is effectively resolved by L-menthyl bromoacetate to afford both <i>S</i><sub>P</sub> and <i>R</i><sub>P</sub> enantiomers of 1-phenylphosphol-2-ene 1-oxide on a multigram scale. The resolved 1-phenylphosphol-2-ene oxide...

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Bibliographic Details
Main Authors: K. Michał Pietrusiewicz, Marek Koprowski, Zbigniew Drzazga, Renata Parcheta, Elżbieta Łastawiecka, Oleg M. Demchuk, Iwona Justyniak
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Symmetry
Subjects:
p-stereogenicity
1-phenylphosphol-2-ene 1-oxide
resolution
[4+2] cycloaddition
polycyclic phosphorus heterocycles
p = o reduction
optically active phosphines
Online Access:https://www.mdpi.com/2073-8994/12/3/346

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https://www.mdpi.com/2073-8994/12/3/346

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