Structure of Heteropentameric GABAA Receptors and Receptor-Anchoring Properties of Gephyrin

Structure of Heteropentameric GABAA Receptors and Receptor-Anchoring Properties of Gephyrin

γ-Aminobutyric acid type A receptors (GABAARs) mediate the majority of fast synaptic inhibition in the central nervous system (CNS). GABAARs belong to the Cys-loop superfamily of pentameric ligand-gated ion channels (pLGIC) and are assembled from 19 different subunits. As dysfunctional GABAergic neu...

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Bibliographic Details
Main Authors: Vikram Babu Kasaragod, Hermann Schindelin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
GABAA receptors
gephyrin
diazepam
GABA
PIP2
artemisinin
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00191/full

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