Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis
Inhibitory control (IC) is a fundamental cognitive function showing age-related change across the healthy lifespan. Since different cognitive resources are needed in the two subcomponents of IC (cognitive inhibition and response inhibition), regions of the brain are differentially activated. In this...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.938789/full |
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| author | Jixin Long Xiaoqi Song You Wang You Wang Chanyu Wang Ruiwang Huang Ruibin Zhang Ruibin Zhang |
| author_facet | Jixin Long Xiaoqi Song You Wang You Wang Chanyu Wang Ruiwang Huang Ruibin Zhang Ruibin Zhang |
| author_sort | Jixin Long |
| collection | DOAJ |
| description | Inhibitory control (IC) is a fundamental cognitive function showing age-related change across the healthy lifespan. Since different cognitive resources are needed in the two subcomponents of IC (cognitive inhibition and response inhibition), regions of the brain are differentially activated. In this study, we aimed to determine whether there is a distinct age-related activation pattern in these two subcomponents. A total of 278 fMRI articles were included in the current analysis. Multilevel kernel density analysis was used to provide data on brain activation under each subcomponent of IC. Contrast analyses were conducted to capture the distinct activated brain regions for the two subcomponents, whereas meta-regression analyses were performed to identify brain regions with distinct age-related activation patterns in the two subcomponents of IC. The results showed that the right inferior frontal gyrus and the bilateral insula were activated during the two IC subcomponents. Contrast analyses revealed stronger activation in the superior parietal lobule during cognitive inhibition, whereas stronger activation during response inhibition was observed primarily in the right inferior frontal gyrus, bilateral insula, and angular gyrus. Furthermore, regression analyses showed that activation of the left anterior cingulate cortex, left inferior frontal gyrus, bilateral insula, and left superior parietal lobule increased and decreased with age during cognitive inhibition and response inhibition, respectively. The results showed distinct activation patterns of aging for the two subcomponents of IC, which may be related to the differential cognitive resources recruited. These findings may help to enhance knowledge of age-related changes in the activation patterns of IC. |
| first_indexed | 2024-03-13T03:37:19Z |
| format | Article |
| id | doaj.art-43749cd1a04e4bc6b5b60f91244afc5b |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-13T03:37:19Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-43749cd1a04e4bc6b5b60f91244afc5b2023-06-23T16:05:55ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.938789938789Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysisJixin Long0Xiaoqi Song1You Wang2You Wang3Chanyu Wang4Ruiwang Huang5Ruibin Zhang6Ruibin Zhang7Cognitive Control and Brain Healthy Laboratory, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, ChinaCognitive Control and Brain Healthy Laboratory, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, ChinaCognitive Control and Brain Healthy Laboratory, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, ChinaDepartment of Psychiatry, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaCognitive Control and Brain Healthy Laboratory, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, ChinaSchool of Psychology, South China Normal University, Guangzhou, ChinaCognitive Control and Brain Healthy Laboratory, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, ChinaDepartment of Psychiatry, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaInhibitory control (IC) is a fundamental cognitive function showing age-related change across the healthy lifespan. Since different cognitive resources are needed in the two subcomponents of IC (cognitive inhibition and response inhibition), regions of the brain are differentially activated. In this study, we aimed to determine whether there is a distinct age-related activation pattern in these two subcomponents. A total of 278 fMRI articles were included in the current analysis. Multilevel kernel density analysis was used to provide data on brain activation under each subcomponent of IC. Contrast analyses were conducted to capture the distinct activated brain regions for the two subcomponents, whereas meta-regression analyses were performed to identify brain regions with distinct age-related activation patterns in the two subcomponents of IC. The results showed that the right inferior frontal gyrus and the bilateral insula were activated during the two IC subcomponents. Contrast analyses revealed stronger activation in the superior parietal lobule during cognitive inhibition, whereas stronger activation during response inhibition was observed primarily in the right inferior frontal gyrus, bilateral insula, and angular gyrus. Furthermore, regression analyses showed that activation of the left anterior cingulate cortex, left inferior frontal gyrus, bilateral insula, and left superior parietal lobule increased and decreased with age during cognitive inhibition and response inhibition, respectively. The results showed distinct activation patterns of aging for the two subcomponents of IC, which may be related to the differential cognitive resources recruited. These findings may help to enhance knowledge of age-related changes in the activation patterns of IC.https://www.frontiersin.org/articles/10.3389/fnagi.2022.938789/fullinhibitory controlresponse inhibitioncognitive inhibitionfMRIaging |
| spellingShingle | Jixin Long Xiaoqi Song You Wang You Wang Chanyu Wang Ruiwang Huang Ruibin Zhang Ruibin Zhang Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis Frontiers in Aging Neuroscience inhibitory control response inhibition cognitive inhibition fMRI aging |
| title | Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis |
| title_full | Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis |
| title_fullStr | Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis |
| title_full_unstemmed | Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis |
| title_short | Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis |
| title_sort | distinct neural activation patterns of age in subcomponents of inhibitory control a fmri meta analysis |
| topic | inhibitory control response inhibition cognitive inhibition fMRI aging |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.938789/full |
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