Clinical effect of venlafaxine combined with methylphenidate hydrochloride on narcolepsy
<p>This study aims to explore the clinical effect of venlafaxine sustained-release capsules combined with methylphenidate hydrochloride tablets on narcolepsy. Thirty-eight cases of narcoleptic patients were randomly divided into venlafaxine combined with methylphenidate hydrochloride treatment...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2013-11-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/847 |
| _version_ | 1819206423301586944 |
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| author | Bin YAN Jin-tao GUO Li-ping LI |
| author_facet | Bin YAN Jin-tao GUO Li-ping LI |
| author_sort | Bin YAN |
| collection | DOAJ |
| description | <p>This study aims to explore the clinical effect of venlafaxine sustained-release capsules combined with methylphenidate hydrochloride tablets on narcolepsy. Thirty-eight cases of narcoleptic patients were randomly divided into venlafaxine combined with methylphenidate hydrochloride treatment group (observation group, N = 19) and methylphenidate hydrochloride and clomipramine treatment group (control group, N = 19). After a total of 12-week treatment, clinical curative effect and adverse drug reactions were observed in 2 groups of patients. The results showed that effective rate of the treatment for excessive daytime sleepiness (EDS) in observation group was higher than that of the control group (15/19 vs 8/19, <em>P</em> = 0.044), and effective rate of the treatment for cataplexy in observation group was higher than that of the control group (13/19 vs 6/19, <em>P</em> = 0.048). The rate of adverse drug reactions in observation group was lower than that in the control group (χ2 = 8.889, <em>P</em> = 0.003). It was indicated that venlafaxine combined with methylphenidate had good curative effect on narcolepsy with EDS and cataplexy symptoms.</p><p> </p><p>doi：10.3969/j.issn.1672-6731.2013.11.010</p> |
| first_indexed | 2024-12-23T05:07:22Z |
| format | Article |
| id | doaj.art-43755885964347bf8ab4d7d63d1082db |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-23T05:07:22Z |
| publishDate | 2013-11-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-43755885964347bf8ab4d7d63d1082db2022-12-21T17:59:02ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312013-11-011311961963846Clinical effect of venlafaxine combined with methylphenidate hydrochloride on narcolepsyBin YAN0Jin-tao GUO1Li-ping LI2Department of Neurology, People's Hospital of Puyang, Puyang 457000, He'nan, ChinaDepartment of Neurology, People's Hospital of Puyang, Puyang 457000, He'nan, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China<p>This study aims to explore the clinical effect of venlafaxine sustained-release capsules combined with methylphenidate hydrochloride tablets on narcolepsy. Thirty-eight cases of narcoleptic patients were randomly divided into venlafaxine combined with methylphenidate hydrochloride treatment group (observation group, N = 19) and methylphenidate hydrochloride and clomipramine treatment group (control group, N = 19). After a total of 12-week treatment, clinical curative effect and adverse drug reactions were observed in 2 groups of patients. The results showed that effective rate of the treatment for excessive daytime sleepiness (EDS) in observation group was higher than that of the control group (15/19 vs 8/19, <em>P</em> = 0.044), and effective rate of the treatment for cataplexy in observation group was higher than that of the control group (13/19 vs 6/19, <em>P</em> = 0.048). The rate of adverse drug reactions in observation group was lower than that in the control group (χ2 = 8.889, <em>P</em> = 0.003). It was indicated that venlafaxine combined with methylphenidate had good curative effect on narcolepsy with EDS and cataplexy symptoms.</p><p> </p><p>doi：10.3969/j.issn.1672-6731.2013.11.010</p>http://www.cjcnn.org/index.php/cjcnn/article/view/847CyclohexanolsMethylphenidateNarcolepsy |
| spellingShingle | Bin YAN Jin-tao GUO Li-ping LI Clinical effect of venlafaxine combined with methylphenidate hydrochloride on narcolepsy Chinese Journal of Contemporary Neurology and Neurosurgery Cyclohexanols Methylphenidate Narcolepsy |
| title | Clinical effect of venlafaxine combined with methylphenidate hydrochloride on narcolepsy |
| title_full | Clinical effect of venlafaxine combined with methylphenidate hydrochloride on narcolepsy |
| title_fullStr | Clinical effect of venlafaxine combined with methylphenidate hydrochloride on narcolepsy |
| title_full_unstemmed | Clinical effect of venlafaxine combined with methylphenidate hydrochloride on narcolepsy |
| title_short | Clinical effect of venlafaxine combined with methylphenidate hydrochloride on narcolepsy |
| title_sort | clinical effect of venlafaxine combined with methylphenidate hydrochloride on narcolepsy |
| topic | Cyclohexanols Methylphenidate Narcolepsy |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/847 |
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