Rational design of heat stable lyophilized rotavirus vaccine formulations

Rational design of heat stable lyophilized rotavirus vaccine formulations

To develop a safe and efficacious heat-stable rotavirus vaccine, new lyophilized formulations were developed using rotavirus serotypes constituting RotaTeq®. A series of formulation compositions, differing in buffering agents, bulking agents, cryoprotectants, amino acids and divalent cations, were s...

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Bibliographic Details
Main Authors: Madhu Madan, Deepa Sikriwal, Gaurav Sharma, Nidhi Shukla, Ashwani Kumar Mandyal, Sachin Kale, Davinder Gill
Format: Article
Language:English
Published: Taylor & Francis Group 2018-09-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
heat-stable vaccines
lyophilization
stability
rotavirus vaccine
cold chain
development
rotavirus
Online Access:http://dx.doi.org/10.1080/21645515.2018.1487499

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