A consensus method for the prediction of 'aggregation-prone' peptides in globular proteins.
The purpose of this work was to construct a consensus prediction algorithm of 'aggregation-prone' peptides in globular proteins, combining existing tools. This allows comparison of the different algorithms and the production of more objective and accurate results. Eleven (11) individual me...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3542318?pdf=render |
| _version_ | 1819236453453922304 |
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| author | Antonios C Tsolis Nikos C Papandreou Vassiliki A Iconomidou Stavros J Hamodrakas |
| author_facet | Antonios C Tsolis Nikos C Papandreou Vassiliki A Iconomidou Stavros J Hamodrakas |
| author_sort | Antonios C Tsolis |
| collection | DOAJ |
| description | The purpose of this work was to construct a consensus prediction algorithm of 'aggregation-prone' peptides in globular proteins, combining existing tools. This allows comparison of the different algorithms and the production of more objective and accurate results. Eleven (11) individual methods are combined and produce AMYLPRED2, a publicly, freely available web tool to academic users (http://biophysics.biol.uoa.gr/AMYLPRED2), for the consensus prediction of amyloidogenic determinants/'aggregation-prone' peptides in proteins, from sequence alone. The performance of AMYLPRED2 indicates that it functions better than individual aggregation-prediction algorithms, as perhaps expected. AMYLPRED2 is a useful tool for identifying amyloid-forming regions in proteins that are associated with several conformational diseases, called amyloidoses, such as Altzheimer's, Parkinson's, prion diseases and type II diabetes. It may also be useful for understanding the properties of protein folding and misfolding and for helping to the control of protein aggregation/solubility in biotechnology (recombinant proteins forming bacterial inclusion bodies) and biotherapeutics (monoclonal antibodies and biopharmaceutical proteins). |
| first_indexed | 2024-12-23T13:04:41Z |
| format | Article |
| id | doaj.art-4378e3e8ef8e413a818c5cc4477e9e92 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T13:04:41Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4378e3e8ef8e413a818c5cc4477e9e922022-12-21T17:45:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5417510.1371/journal.pone.0054175A consensus method for the prediction of 'aggregation-prone' peptides in globular proteins.Antonios C TsolisNikos C PapandreouVassiliki A IconomidouStavros J HamodrakasThe purpose of this work was to construct a consensus prediction algorithm of 'aggregation-prone' peptides in globular proteins, combining existing tools. This allows comparison of the different algorithms and the production of more objective and accurate results. Eleven (11) individual methods are combined and produce AMYLPRED2, a publicly, freely available web tool to academic users (http://biophysics.biol.uoa.gr/AMYLPRED2), for the consensus prediction of amyloidogenic determinants/'aggregation-prone' peptides in proteins, from sequence alone. The performance of AMYLPRED2 indicates that it functions better than individual aggregation-prediction algorithms, as perhaps expected. AMYLPRED2 is a useful tool for identifying amyloid-forming regions in proteins that are associated with several conformational diseases, called amyloidoses, such as Altzheimer's, Parkinson's, prion diseases and type II diabetes. It may also be useful for understanding the properties of protein folding and misfolding and for helping to the control of protein aggregation/solubility in biotechnology (recombinant proteins forming bacterial inclusion bodies) and biotherapeutics (monoclonal antibodies and biopharmaceutical proteins).http://europepmc.org/articles/PMC3542318?pdf=render |
| spellingShingle | Antonios C Tsolis Nikos C Papandreou Vassiliki A Iconomidou Stavros J Hamodrakas A consensus method for the prediction of 'aggregation-prone' peptides in globular proteins. PLoS ONE |
| title | A consensus method for the prediction of 'aggregation-prone' peptides in globular proteins. |
| title_full | A consensus method for the prediction of 'aggregation-prone' peptides in globular proteins. |
| title_fullStr | A consensus method for the prediction of 'aggregation-prone' peptides in globular proteins. |
| title_full_unstemmed | A consensus method for the prediction of 'aggregation-prone' peptides in globular proteins. |
| title_short | A consensus method for the prediction of 'aggregation-prone' peptides in globular proteins. |
| title_sort | consensus method for the prediction of aggregation prone peptides in globular proteins |
| url | http://europepmc.org/articles/PMC3542318?pdf=render |
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