The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age
Borderline ovarian tumors (BOTs) account for approximately 15% of all epithelial ovarian cancers. In 80% of cases the diagnosis of BOTs is done at stage I and more than a third of BOTs occurs in women younger than 40 years of age wishing to preserve their childbearing potential; the issue of conserv...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.973034/full |
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| author | Luigi Della Corte Antonio Mercorio Paolo Serafino Francesco Viciglione Mario Palumbo Maria Chiara De Angelis Maria Borgo Cira Buonfantino Marina Tesorone Giuseppe Bifulco Pierluigi Giampaolino |
| author_facet | Luigi Della Corte Antonio Mercorio Paolo Serafino Francesco Viciglione Mario Palumbo Maria Chiara De Angelis Maria Borgo Cira Buonfantino Marina Tesorone Giuseppe Bifulco Pierluigi Giampaolino |
| author_sort | Luigi Della Corte |
| collection | DOAJ |
| description | Borderline ovarian tumors (BOTs) account for approximately 15% of all epithelial ovarian cancers. In 80% of cases the diagnosis of BOTs is done at stage I and more than a third of BOTs occurs in women younger than 40 years of age wishing to preserve their childbearing potential; the issue of conservative surgical management (fertility-sparing treatment) is thus becoming of paramount importance. At early stages, the modalities of conservative treatment could range from mono-lateral cystectomy to bilateral salpingo-oophorectomy. Although cystectomy is the preferred method to promote fertility it can lead to an elevated risk of recurrence; therefore, an appropriate counseling about the risk of relapse is mandatory before opting for this treatment. Nevertheless, relapses are often benign and can be treated by repeated conservative surgery. Besides the stage of the disease, histological subtype is another essential factor when considering the proper procedure: as most mucinous BOTs (mBOTs) are more commonly unilateral, the risk of an invasive recurrence seems to be higher, compared to serous histotype, therefore unilateral salpingo-oophorectomy is recommended. In the appraisal of current literature, this review aims to gain better insight on the current recommendations to identify the right balance between an accurate staging and an optimal fertility outcome. |
| first_indexed | 2024-04-11T21:54:47Z |
| format | Article |
| id | doaj.art-437a8be6126f40c4a2c1137c4a1f00e6 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-11T21:54:47Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-437a8be6126f40c4a2c1137c4a1f00e62022-12-22T04:01:09ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-08-01910.3389/fsurg.2022.973034973034The challenging management of borderline ovarian tumors (BOTs) in women of childbearing ageLuigi Della Corte0Antonio Mercorio1Paolo Serafino2Francesco Viciglione3Mario Palumbo4Maria Chiara De Angelis5Maria Borgo6Cira Buonfantino7Marina Tesorone8Giuseppe Bifulco9Pierluigi Giampaolino10Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, ItalyDepartment of Public Health, University of Naples Federico II, Naples, ItalyDepartment of Public Health, University of Naples Federico II, Naples, ItalyDepartment of Public Health, University of Naples Federico II, Naples, ItalyDepartment of Child and Adolescent Health, U.O.C Protection of Women's- ASL Napoli 1, Naples, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, ItalyDepartment of Public Health, University of Naples Federico II, Naples, ItalyBorderline ovarian tumors (BOTs) account for approximately 15% of all epithelial ovarian cancers. In 80% of cases the diagnosis of BOTs is done at stage I and more than a third of BOTs occurs in women younger than 40 years of age wishing to preserve their childbearing potential; the issue of conservative surgical management (fertility-sparing treatment) is thus becoming of paramount importance. At early stages, the modalities of conservative treatment could range from mono-lateral cystectomy to bilateral salpingo-oophorectomy. Although cystectomy is the preferred method to promote fertility it can lead to an elevated risk of recurrence; therefore, an appropriate counseling about the risk of relapse is mandatory before opting for this treatment. Nevertheless, relapses are often benign and can be treated by repeated conservative surgery. Besides the stage of the disease, histological subtype is another essential factor when considering the proper procedure: as most mucinous BOTs (mBOTs) are more commonly unilateral, the risk of an invasive recurrence seems to be higher, compared to serous histotype, therefore unilateral salpingo-oophorectomy is recommended. In the appraisal of current literature, this review aims to gain better insight on the current recommendations to identify the right balance between an accurate staging and an optimal fertility outcome.https://www.frontiersin.org/articles/10.3389/fsurg.2022.973034/fullbordeline ovarian tumorconservative surgeryovaryfertilityrecurrencesurvival |
| spellingShingle | Luigi Della Corte Antonio Mercorio Paolo Serafino Francesco Viciglione Mario Palumbo Maria Chiara De Angelis Maria Borgo Cira Buonfantino Marina Tesorone Giuseppe Bifulco Pierluigi Giampaolino The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age Frontiers in Surgery bordeline ovarian tumor conservative surgery ovary fertility recurrence survival |
| title | The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age |
| title_full | The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age |
| title_fullStr | The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age |
| title_full_unstemmed | The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age |
| title_short | The challenging management of borderline ovarian tumors (BOTs) in women of childbearing age |
| title_sort | challenging management of borderline ovarian tumors bots in women of childbearing age |
| topic | bordeline ovarian tumor conservative surgery ovary fertility recurrence survival |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.973034/full |
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