Functional changes in prefrontal cortex following frequency-specific training
Abstract Numerous studies indicate a significant role of pre-frontal circuits (PFC) connectivity involving attentional and reward neural networks within attention deficit hyperactivity disorder (ADHD) pathophysiology. To date, the neural mechanisms underlying the utility of non-invasive frequency-sp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-24088-7 |
| _version_ | 1811304478024925184 |
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| author | Lana Bach-Morrow Francesco Boccalatte Antonio DeRosa David Devos Carmen Garcia-Sanchez Matilde Inglese Amgad Droby |
| author_facet | Lana Bach-Morrow Francesco Boccalatte Antonio DeRosa David Devos Carmen Garcia-Sanchez Matilde Inglese Amgad Droby |
| author_sort | Lana Bach-Morrow |
| collection | DOAJ |
| description | Abstract Numerous studies indicate a significant role of pre-frontal circuits (PFC) connectivity involving attentional and reward neural networks within attention deficit hyperactivity disorder (ADHD) pathophysiology. To date, the neural mechanisms underlying the utility of non-invasive frequency-specific training systems in ADHD remediation remain underexplored. To address this issue, we created a portable electroencephalography (EEG)-based wireless system consisting of a novel headset, electrodes, and neuro program, named frequency specific cognitive training (FSCT). In a double-blind, randomized, controlled study we investigated the training effects in N = 46 school-age children ages 6–18 years with ADHD. 23 children in experimental group who underwent FCST training showed an increase in scholastic performance and meliorated their performance on neuropsychological tests associated with executive functions and memory. Their results were compared to 23 age-matched participants who underwent training with placebo (pFSCT). Electroencephalogram (EEG) data collected from participants trained with FSCT showed a significant increase in 14–18 Hz EEG frequencies in PFC brain regions, activities that indicated brain activation in frontal brain regions, the caudate nucleus, and putamen. These results demonstrate that FSCT targets specific prefrontal and striatal areas in children with ADHD, suggesting a beneficial modality for non-invasive modulation of brain areas implicated in attention and executive functions. |
| first_indexed | 2024-04-13T08:07:52Z |
| format | Article |
| id | doaj.art-437ad554328d4c0494ca47083b430ad4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T08:07:52Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-437ad554328d4c0494ca47083b430ad42022-12-22T02:55:06ZengNature PortfolioScientific Reports2045-23222022-11-0112111010.1038/s41598-022-24088-7Functional changes in prefrontal cortex following frequency-specific trainingLana Bach-Morrow0Francesco Boccalatte1Antonio DeRosa2David Devos3Carmen Garcia-Sanchez4Matilde Inglese5Amgad Droby6Think InterfacesDepartment of Pathology, NYU Langone Medical CenterDepartment of Mathematics, University of MarylandDepartment of Neurology, University Hospital, Univ of LilleNeuropsychology Unit, Neurology Service, Hospital de Sant PauNeurology Department, Icahn School of Medicine at Mount SinaiNeurology Department, Icahn School of Medicine at Mount SinaiAbstract Numerous studies indicate a significant role of pre-frontal circuits (PFC) connectivity involving attentional and reward neural networks within attention deficit hyperactivity disorder (ADHD) pathophysiology. To date, the neural mechanisms underlying the utility of non-invasive frequency-specific training systems in ADHD remediation remain underexplored. To address this issue, we created a portable electroencephalography (EEG)-based wireless system consisting of a novel headset, electrodes, and neuro program, named frequency specific cognitive training (FSCT). In a double-blind, randomized, controlled study we investigated the training effects in N = 46 school-age children ages 6–18 years with ADHD. 23 children in experimental group who underwent FCST training showed an increase in scholastic performance and meliorated their performance on neuropsychological tests associated with executive functions and memory. Their results were compared to 23 age-matched participants who underwent training with placebo (pFSCT). Electroencephalogram (EEG) data collected from participants trained with FSCT showed a significant increase in 14–18 Hz EEG frequencies in PFC brain regions, activities that indicated brain activation in frontal brain regions, the caudate nucleus, and putamen. These results demonstrate that FSCT targets specific prefrontal and striatal areas in children with ADHD, suggesting a beneficial modality for non-invasive modulation of brain areas implicated in attention and executive functions.https://doi.org/10.1038/s41598-022-24088-7 |
| spellingShingle | Lana Bach-Morrow Francesco Boccalatte Antonio DeRosa David Devos Carmen Garcia-Sanchez Matilde Inglese Amgad Droby Functional changes in prefrontal cortex following frequency-specific training Scientific Reports |
| title | Functional changes in prefrontal cortex following frequency-specific training |
| title_full | Functional changes in prefrontal cortex following frequency-specific training |
| title_fullStr | Functional changes in prefrontal cortex following frequency-specific training |
| title_full_unstemmed | Functional changes in prefrontal cortex following frequency-specific training |
| title_short | Functional changes in prefrontal cortex following frequency-specific training |
| title_sort | functional changes in prefrontal cortex following frequency specific training |
| url | https://doi.org/10.1038/s41598-022-24088-7 |
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