An Exploration of the Safety of “Pneumonia Prevention No. 1” in Healthy Populations
Zuo-Huan Meng,1,* Wen-Yuan Ma,1,* Ying Wang,2 Ya-Rong Li,2 Jing Zhang,3 Yin-Fang Liu,4 Xin-Ke Zhao,5,6 Chun-He Da6 1Institute of Traditional Chinese Medicine, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, People’s Republic of China; 2Department of Pharmacy,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-11-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/an-exploration-of-the-safety-of-pneumonia-prevention-no-1-in-healthy-p-peer-reviewed-fulltext-article-IDR |
| _version_ | 1828183198571429888 |
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| author | Meng ZH Ma WY Wang Y Li YR Zhang J Liu YF Zhao XK Da CH |
| author_facet | Meng ZH Ma WY Wang Y Li YR Zhang J Liu YF Zhao XK Da CH |
| author_sort | Meng ZH |
| collection | DOAJ |
| description | Zuo-Huan Meng,1,* Wen-Yuan Ma,1,* Ying Wang,2 Ya-Rong Li,2 Jing Zhang,3 Yin-Fang Liu,4 Xin-Ke Zhao,5,6 Chun-He Da6 1Institute of Traditional Chinese Medicine, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, People’s Republic of China; 2Department of Pharmacy, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, People’s Republic of China; 3Nutrition Department, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, People’s Republic of China; 4Respiratory Medicine, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, People’s Republic of China; 5Gansu University of Chinese Medicine, Lanzhou, People’s Republic of China; 6The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zuo-Huan Meng, Institute of Traditional Chinese Medicine, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, 730900, People’s Republic of China, Tel +8609438813373, Email 441390739@qq.com Chun-He Da, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, 730900, People’s Republic of China, Tel +8609438810612, Email dachunhedch@outlook.comBackground: “Pneumonia Prevention No.1” belongs to ‘traditional Chinese medicine prescription for prevention of viral pneumonia and influenza’ was urgently formulated by Notice on Printing the Novel Coronavirus Diagnosis and Treatment Scheme for COVID-19 (Trial Version 3) and Traditional Chinese Medicine Prevention and Treatment Scheme for COVID-19 in Hubei Province (Trial). Because the prescription drug has the bidirectional regulation function of human immune function, moderate improvement of immune function can effectively resist virus invasion, while excessive immune function will produce immune overresponse. Excessive immune response will aggravate the condition of patients with COVID-19, resulting in the death of severe patients.Methods: Twenty medical workers aged 20– 60 years old, who had no immune disease, no current disease and healthy physical examination, were selected as participants. The participants took Hubei “Pneumonia Prevention No.1” decoction, one dosage each day, twice a day, for 7 consecutive days. With the before-after control method, blood samples were collected from the median cubital veins before and after medication. Immunoglobulin IgA, IgG and IgM were measured by immunoturbidimetry, and T lymphocyte subsets CD3, CD4, CD8 and CD4/CD8 were measured by flow cytometry. The changes of indexes before and after medication were compared with SPPS 13.0 statistical software. The data were expressed by (mean ± standard deviation). T-test was adopted, and P < 0.05 was considered statistically significant (P < 0.05).Results: The results of this study show that in healthy participants, the immunoglobulin and T lymphocyte subsets did not differ significantly before and after drug administration (P > 0.05).Conclusion: Under normal drug administration circumstances, “Pneumonia Prevention No. 1” had no significant regulating effect on the immune system in a healthy population and did not increase the immune system capacity beyond a reasonable range. It is safe to be used as a prophylactic measure in healthy populations.Keywords: “Pneumonia Prevention No. 1”, healthy population, immunoglobulin, T lymphocyte, safe medication |
| first_indexed | 2024-04-12T06:28:57Z |
| format | Article |
| id | doaj.art-437d04ff6b8c461185229e711e078f75 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-12T06:28:57Z |
| publishDate | 2022-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-437d04ff6b8c461185229e711e078f752022-12-22T03:44:03ZengDove Medical PressInfection and Drug Resistance1178-69732022-11-01Volume 156695670179841An Exploration of the Safety of “Pneumonia Prevention No. 1” in Healthy PopulationsMeng ZHMa WYWang YLi YRZhang JLiu YFZhao XKDa CHZuo-Huan Meng,1,* Wen-Yuan Ma,1,* Ying Wang,2 Ya-Rong Li,2 Jing Zhang,3 Yin-Fang Liu,4 Xin-Ke Zhao,5,6 Chun-He Da6 1Institute of Traditional Chinese Medicine, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, People’s Republic of China; 2Department of Pharmacy, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, People’s Republic of China; 3Nutrition Department, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, People’s Republic of China; 4Respiratory Medicine, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, People’s Republic of China; 5Gansu University of Chinese Medicine, Lanzhou, People’s Republic of China; 6The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zuo-Huan Meng, Institute of Traditional Chinese Medicine, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, 730900, People’s Republic of China, Tel +8609438813373, Email 441390739@qq.com Chun-He Da, The Third Affiliated Hospital of Gansu University of Chinese Medicine, Baiyin, 730900, People’s Republic of China, Tel +8609438810612, Email dachunhedch@outlook.comBackground: “Pneumonia Prevention No.1” belongs to ‘traditional Chinese medicine prescription for prevention of viral pneumonia and influenza’ was urgently formulated by Notice on Printing the Novel Coronavirus Diagnosis and Treatment Scheme for COVID-19 (Trial Version 3) and Traditional Chinese Medicine Prevention and Treatment Scheme for COVID-19 in Hubei Province (Trial). Because the prescription drug has the bidirectional regulation function of human immune function, moderate improvement of immune function can effectively resist virus invasion, while excessive immune function will produce immune overresponse. Excessive immune response will aggravate the condition of patients with COVID-19, resulting in the death of severe patients.Methods: Twenty medical workers aged 20– 60 years old, who had no immune disease, no current disease and healthy physical examination, were selected as participants. The participants took Hubei “Pneumonia Prevention No.1” decoction, one dosage each day, twice a day, for 7 consecutive days. With the before-after control method, blood samples were collected from the median cubital veins before and after medication. Immunoglobulin IgA, IgG and IgM were measured by immunoturbidimetry, and T lymphocyte subsets CD3, CD4, CD8 and CD4/CD8 were measured by flow cytometry. The changes of indexes before and after medication were compared with SPPS 13.0 statistical software. The data were expressed by (mean ± standard deviation). T-test was adopted, and P < 0.05 was considered statistically significant (P < 0.05).Results: The results of this study show that in healthy participants, the immunoglobulin and T lymphocyte subsets did not differ significantly before and after drug administration (P > 0.05).Conclusion: Under normal drug administration circumstances, “Pneumonia Prevention No. 1” had no significant regulating effect on the immune system in a healthy population and did not increase the immune system capacity beyond a reasonable range. It is safe to be used as a prophylactic measure in healthy populations.Keywords: “Pneumonia Prevention No. 1”, healthy population, immunoglobulin, T lymphocyte, safe medicationhttps://www.dovepress.com/an-exploration-of-the-safety-of-pneumonia-prevention-no-1-in-healthy-p-peer-reviewed-fulltext-article-IDR“pneumonia prevention no. 1”healthy populationimmunoglobulint lymphocytesafe medication |
| spellingShingle | Meng ZH Ma WY Wang Y Li YR Zhang J Liu YF Zhao XK Da CH An Exploration of the Safety of “Pneumonia Prevention No. 1” in Healthy Populations Infection and Drug Resistance “pneumonia prevention no. 1” healthy population immunoglobulin t lymphocyte safe medication |
| title | An Exploration of the Safety of “Pneumonia Prevention No. 1” in Healthy Populations |
| title_full | An Exploration of the Safety of “Pneumonia Prevention No. 1” in Healthy Populations |
| title_fullStr | An Exploration of the Safety of “Pneumonia Prevention No. 1” in Healthy Populations |
| title_full_unstemmed | An Exploration of the Safety of “Pneumonia Prevention No. 1” in Healthy Populations |
| title_short | An Exploration of the Safety of “Pneumonia Prevention No. 1” in Healthy Populations |
| title_sort | exploration of the safety of ldquo pneumonia prevention no 1 rdquo in healthy populations |
| topic | “pneumonia prevention no. 1” healthy population immunoglobulin t lymphocyte safe medication |
| url | https://www.dovepress.com/an-exploration-of-the-safety-of-pneumonia-prevention-no-1-in-healthy-p-peer-reviewed-fulltext-article-IDR |
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