Fabrication of an Au-doped Cu/Fe oxide-polymer core–shell nanoreactor with chemodynamic and photodynamic dual effects as potential cancer therapeutic agents
Abstract Nanoparticles are widely used in biomedical applications and cancer treatments due to their minute scale, multi-function, and long retention time. Among the various nanoparticles, the unique optical property derived from the localized surface plasmon resonance effect of metallic nanoparticl...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23002-5 |
| _version_ | 1811223633960370176 |
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| author | Chun-Kai Sun Yin-Hsu Wang Yu-Liang Chen Ting-Yu Lu Hsi-Ying Chen Shih-Chin Pan Po-Chun Chen Mei-Yi Liao Jiashing Yu |
| author_facet | Chun-Kai Sun Yin-Hsu Wang Yu-Liang Chen Ting-Yu Lu Hsi-Ying Chen Shih-Chin Pan Po-Chun Chen Mei-Yi Liao Jiashing Yu |
| author_sort | Chun-Kai Sun |
| collection | DOAJ |
| description | Abstract Nanoparticles are widely used in biomedical applications and cancer treatments due to their minute scale, multi-function, and long retention time. Among the various nanoparticles, the unique optical property derived from the localized surface plasmon resonance effect of metallic nanoparticles is a primary reason that metallic nanoparticles are researched and applied. Copper and Iron nanoparticles have the potential to generate hydroxyl radicals in excess H2O2 via Fenton or Fenton-like reactions. On the other hand, gold nanoparticles equipped with a photosensitizer can transfer the energy of photons to chemical energy and enhance the production of singlet oxygen, which is suitable for cancer treatment. With the actions of these two reactive oxygen species in the tumor microenvironment, cell apoptosis can further be induced. In this work, we first synthesized dual metal nanoparticles with poly[styrene-alt-(maleic acid, sodium salt)(Cu ferrite oxide-polymer) by a simple one-step hydrothermal reduction reaction. Then, gold(III) was reduced and doped into the structure, which formed a triple metal structure, Au-doped Cu ferrite nanoparticles (Au/Cu ferrite oxide-polymer NPs). The metal ratio of the product could be controlled by manipulating the Fe/Cu ratio of reactants and the sequence of addition of reactants. The core–shell structure was verified by transmission electron microscopy. Moreover, the hydroxyl radical and singlet oxygen generation ability of Au/Cu ferrite oxide-polymer was proved. The chemodynamic and photodynamic effect was measured, and the in vitro ROS generation was observed. Furthermore, the behavior of endocytosis by cancer cells could be controlled by the magnetic field. The result indicated that Au/Cu ferrite oxide-polymer core–shell nanoreactor is a potential agent for chemodynamic/photodynamic synergetic therapy. |
| first_indexed | 2024-04-12T08:36:08Z |
| format | Article |
| id | doaj.art-437d132d4d5a485ca68b3a5d69ab5ccb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T08:36:08Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-437d132d4d5a485ca68b3a5d69ab5ccb2022-12-22T03:40:00ZengNature PortfolioScientific Reports2045-23222022-11-0112111210.1038/s41598-022-23002-5Fabrication of an Au-doped Cu/Fe oxide-polymer core–shell nanoreactor with chemodynamic and photodynamic dual effects as potential cancer therapeutic agentsChun-Kai Sun0Yin-Hsu Wang1Yu-Liang Chen2Ting-Yu Lu3Hsi-Ying Chen4Shih-Chin Pan5Po-Chun Chen6Mei-Yi Liao7Jiashing Yu8Department of Chemical Engineering, National Taiwan UniversityDepartment of Chemical Engineering, National Taiwan UniversityDepartment of Chemical Engineering, National Taiwan UniversityMaterials Science and Engineering Program, University of California San DiegoDepartment of Applied Chemistry, National Pingtung UniversityDepartment of Materials and Mineral Resources Engineering, Institute of Materials Science and Engineering, National Taipei University of TechnologyDepartment of Materials and Mineral Resources Engineering, Institute of Materials Science and Engineering, National Taipei University of TechnologyDepartment of Applied Chemistry, National Pingtung UniversityDepartment of Chemical Engineering, National Taiwan UniversityAbstract Nanoparticles are widely used in biomedical applications and cancer treatments due to their minute scale, multi-function, and long retention time. Among the various nanoparticles, the unique optical property derived from the localized surface plasmon resonance effect of metallic nanoparticles is a primary reason that metallic nanoparticles are researched and applied. Copper and Iron nanoparticles have the potential to generate hydroxyl radicals in excess H2O2 via Fenton or Fenton-like reactions. On the other hand, gold nanoparticles equipped with a photosensitizer can transfer the energy of photons to chemical energy and enhance the production of singlet oxygen, which is suitable for cancer treatment. With the actions of these two reactive oxygen species in the tumor microenvironment, cell apoptosis can further be induced. In this work, we first synthesized dual metal nanoparticles with poly[styrene-alt-(maleic acid, sodium salt)(Cu ferrite oxide-polymer) by a simple one-step hydrothermal reduction reaction. Then, gold(III) was reduced and doped into the structure, which formed a triple metal structure, Au-doped Cu ferrite nanoparticles (Au/Cu ferrite oxide-polymer NPs). The metal ratio of the product could be controlled by manipulating the Fe/Cu ratio of reactants and the sequence of addition of reactants. The core–shell structure was verified by transmission electron microscopy. Moreover, the hydroxyl radical and singlet oxygen generation ability of Au/Cu ferrite oxide-polymer was proved. The chemodynamic and photodynamic effect was measured, and the in vitro ROS generation was observed. Furthermore, the behavior of endocytosis by cancer cells could be controlled by the magnetic field. The result indicated that Au/Cu ferrite oxide-polymer core–shell nanoreactor is a potential agent for chemodynamic/photodynamic synergetic therapy.https://doi.org/10.1038/s41598-022-23002-5 |
| spellingShingle | Chun-Kai Sun Yin-Hsu Wang Yu-Liang Chen Ting-Yu Lu Hsi-Ying Chen Shih-Chin Pan Po-Chun Chen Mei-Yi Liao Jiashing Yu Fabrication of an Au-doped Cu/Fe oxide-polymer core–shell nanoreactor with chemodynamic and photodynamic dual effects as potential cancer therapeutic agents Scientific Reports |
| title | Fabrication of an Au-doped Cu/Fe oxide-polymer core–shell nanoreactor with chemodynamic and photodynamic dual effects as potential cancer therapeutic agents |
| title_full | Fabrication of an Au-doped Cu/Fe oxide-polymer core–shell nanoreactor with chemodynamic and photodynamic dual effects as potential cancer therapeutic agents |
| title_fullStr | Fabrication of an Au-doped Cu/Fe oxide-polymer core–shell nanoreactor with chemodynamic and photodynamic dual effects as potential cancer therapeutic agents |
| title_full_unstemmed | Fabrication of an Au-doped Cu/Fe oxide-polymer core–shell nanoreactor with chemodynamic and photodynamic dual effects as potential cancer therapeutic agents |
| title_short | Fabrication of an Au-doped Cu/Fe oxide-polymer core–shell nanoreactor with chemodynamic and photodynamic dual effects as potential cancer therapeutic agents |
| title_sort | fabrication of an au doped cu fe oxide polymer core shell nanoreactor with chemodynamic and photodynamic dual effects as potential cancer therapeutic agents |
| url | https://doi.org/10.1038/s41598-022-23002-5 |
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