Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ab...

Full description

Bibliographic Details
Main Authors:	Mehdi Sharifi-Rad, Chintha Lankatillake, Daniel A. Dias, Anca Oana Docea, Mohamad Fawzi Mahomoodally, Devina Lobine, Paul L. Chazot, Begum Kurt, Tugba Boyunegmez Tumer, Ana Catarina Moreira, Farukh Sharopov, Miquel Martorell, Natália Martins, William C. Cho, Daniela Calina, Javad Sharifi-Rad
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Series:	Journal of Clinical Medicine
Subjects:	neurodegenerative disorders Alzheimer’s disease dementias Parkinson’s disease natural compounds plants secondary metabolites
Online Access:	https://www.mdpi.com/2077-0383/9/4/1061

Similar Items

Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
by: Bahare Salehi, et al.
Published: (2019-08-01)

Epibatidine: A Promising Natural Alkaloid in Health
by: Bahare Salehi, et al.
Published: (2018-12-01)

Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives
by: Chandan Sarkar, et al.
Published: (2020-09-01)

Therapeutic potential of cranberry for kidney health and diseases
by: Ruhul Amin, et al.
Published: (2022-10-01)

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion
by: Mehdi Sharifi-Rad, et al.
Published: (2018-07-01)

Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action
by: Javad Sharifi-Rad, et al.
Published: (2021-08-01)

Pharmacotherapeutics Applications and Chemistry of Chalcone Derivatives
by: Jagjit Singh Dhaliwal, et al.
Published: (2022-10-01)

Neurodegeneration and the pharmacotherapeutic aspect of Alzheimer's disease
by: Żaneta Binert-Kusztal, et al.
Published: (2021-09-01)

Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases
by: Priya Chaudhary, et al.
Published: (2023-05-01)

Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases
by: Walther Bild, et al.
Published: (2022-10-01)

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases
by: Mehdi Sharifi-Rad, et al.
Published: (2020-07-01)

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited
by: Bahare Salehi, et al.
Published: (2020-01-01)

Pharmacotherapeutic potential of pomegranate in age-related neurological disorders
by: Mohammad Javad Emami Kazemabad, et al.
Published: (2022-09-01)

An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms
by: Muhammad Torequl Islam, et al.
Published: (2023-03-01)

Curcumin‐loaded nanomedicines as therapeutic strategy in malaria management
by: Ruhul Amin, et al.
Published: (2023-10-01)

Preclinical Activities of Epigallocatechin Gallate in Signaling Pathways in Cancer
by: Mehdi Sharifi-Rad, et al.
Published: (2020-01-01)

Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action
by: Javad Sharifi-Rad, et al.
Published: (2020-10-01)

Natural products of relevance in the management of attention deficit hyperactivity disorder
by: Luísa Custódio, et al.
Published: (2023-02-01)

Apoptosis evasion via long non-coding RNAs in colorectal cancer
by: Muhammad Irfan, et al.
Published: (2022-09-01)

Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases
by: Darkovska-Serafimovska M, et al.
Published: (2018-04-01)

Melatonin in Medicinal and Food Plants: Occurrence, Bioavailability, and Health Potential for Humans
by: Bahare Salehi, et al.
Published: (2019-07-01)

An Update on Current Pharmacotherapeutic Options for the Treatment of Ulcerative Colitis
by: Francesca Ferretti, et al.
Published: (2022-04-01)

Botanical Products in the Treatment and Control of Schistosomiasis: Recent Studies and Distribution of Active Plant Resources According to Affected Regions
by: Ricardo Diego Duarte Galhardo de Albuquerque, et al.
Published: (2020-08-01)

Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease
by: Sandra Franco-Iborra, et al.
Published: (2018-05-01)

Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases
by: Chaudhary, Priya, et al.
Published: (2023)

The Therapeutic Potential of Naringenin: A Review of Clinical Trials
by: Bahare Salehi, et al.
Published: (2019-01-01)

Dataset on the differentiation of THP-1 monocytes to LPS inducible adherent macrophages and their capacity for NO/iNOS signaling
by: Adem Ozleyen, et al.
Published: (2021-04-01)

Current and Emerging Pharmacotherapeutic Interventions for the Treatment of Peripheral Nerve Disorders
by: Jeremy Chung Bo Chiang, et al.
Published: (2022-05-01)

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence
by: Bahare Salehi, et al.
Published: (2021-01-01)

Pharmacotherapeutic considerations for chronic pain in chronic kidney and end-stage renal disease
by: Mathew RO, et al.
Published: (2016-12-01)

Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health
by: Bahare Salehi, et al.
Published: (2020-05-01)

<i>Lamium</i> Plants—A Comprehensive Review on Health Benefits and Biological Activities
by: Bahare Salehi, et al.
Published: (2019-05-01)

Therapeutic Potential of Neoechinulins and Their Derivatives: An Overview of the Molecular Mechanisms Behind Pharmacological Activities
by: Javad Sharifi-Rad, et al.
Published: (2021-07-01)

Antimicrobial prescriptions in cancer patients: An evaluation based on clinical and pharmacotherapeutic indicators
by: Dorgerys García Falcón, et al.
Published: (2022-05-01)

Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants
by: Chintha Lankatillake, et al.
Published: (2019-09-01)

Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
by: Javad Sharifi-Rad, et al.
Published: (2022-09-01)

Understanding Camellia sinensis using Omics Technologies along with Endophytic Bacteria and Environmental Roles on Metabolism: A Review
by: Phumudzo Patrick Tshikhudo, et al.
Published: (2019-01-01)

The Effect of Genotyping on the Number of Pharmacotherapeutic Gene–Drug Interventions in Chronic Kidney Disease Patients
by: Catharina H. M. Kerskes, et al.
Published: (2023-04-01)

Piper species: a comprehensive review on their phytochemistry, biological activities and applications
by: Salehi, Bahare, et al.
Published: (2019)

<i>Piper</i> Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications
by: Bahare Salehi, et al.
Published: (2019-04-01)