Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study
Background: The objective of this is preclinical investigation was to evaluate the differential drug sustainability and pharmacodynamic properties of two local minocycline microsphere carriers: chitosan-coated alginate (CA) and poly(meth)acrylate-glycerin (PG). Methods: Four dental implants were pla...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/7/668 |
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| author | Sung-Wook Yoon Myong-Ji Kim Kyeong-Won Paeng Kyeong Ae Yu Chong-Kil Lee Young Woo Song Jae-Kook Cha Mariano Sanz Ui-Won Jung |
| author_facet | Sung-Wook Yoon Myong-Ji Kim Kyeong-Won Paeng Kyeong Ae Yu Chong-Kil Lee Young Woo Song Jae-Kook Cha Mariano Sanz Ui-Won Jung |
| author_sort | Sung-Wook Yoon |
| collection | DOAJ |
| description | Background: The objective of this is preclinical investigation was to evaluate the differential drug sustainability and pharmacodynamic properties of two local minocycline microsphere carriers: chitosan-coated alginate (CA) and poly(meth)acrylate-glycerin (PG). Methods: Four dental implants were placed unilaterally in the edentulous mandible of six beagle dogs. Each implant was randomly assigned to receive one of the following four treatments: (i) CA (CA-based minocycline), (ii) placebo (CA substrate without minocycline), (iii) PG (PG-based minocycline) and (iv) control (mechanical debridement only). After inducing peri-implant mucositis, the randomly assigned treatments were administered into the gingival sulcus twice at a 4-week interval using a plastic-tipped syringe. Drug sustainability and pharmacodynamic (clinical, radiographical and cell marker intensity) evaluations were performed after each administration. Results: The CA microspheres remained longer around the healing abutment compared to the PG microspheres at both administrations and a longer bacteriostatic effect was observed from CA (7.0 ± 5.7 days) compared to PG (1.2 ± 2.6 days). The efficacy of the applied therapies based on clinical, radiographical and histological analyses were comparable across all treatment groups. Conclusions: CA microspheres showed longer carrier and bacteriostatic effect sustainability when compared to PG microspheres, however, longer drug sustainability did not lead to improved treatment outcomes. |
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| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T18:26:33Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj.art-437e1c53cf8145088d978dcdeec0aaf02023-11-20T06:59:13ZengMDPI AGPharmaceutics1999-49232020-07-0112766810.3390/pharmaceutics12070668Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo StudySung-Wook Yoon0Myong-Ji Kim1Kyeong-Won Paeng2Kyeong Ae Yu3Chong-Kil Lee4Young Woo Song5Jae-Kook Cha6Mariano Sanz7Ui-Won Jung8Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03772, KoreaDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03772, KoreaDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03772, KoreaCollege of Pharmacy, Chungbuk National University, Cheongju 28165, KoreaCollege of Pharmacy, Chungbuk National University, Cheongju 28165, KoreaDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03772, KoreaDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03772, KoreaSection of Graduate Periodontology, Faculty of Odontology, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03772, KoreaBackground: The objective of this is preclinical investigation was to evaluate the differential drug sustainability and pharmacodynamic properties of two local minocycline microsphere carriers: chitosan-coated alginate (CA) and poly(meth)acrylate-glycerin (PG). Methods: Four dental implants were placed unilaterally in the edentulous mandible of six beagle dogs. Each implant was randomly assigned to receive one of the following four treatments: (i) CA (CA-based minocycline), (ii) placebo (CA substrate without minocycline), (iii) PG (PG-based minocycline) and (iv) control (mechanical debridement only). After inducing peri-implant mucositis, the randomly assigned treatments were administered into the gingival sulcus twice at a 4-week interval using a plastic-tipped syringe. Drug sustainability and pharmacodynamic (clinical, radiographical and cell marker intensity) evaluations were performed after each administration. Results: The CA microspheres remained longer around the healing abutment compared to the PG microspheres at both administrations and a longer bacteriostatic effect was observed from CA (7.0 ± 5.7 days) compared to PG (1.2 ± 2.6 days). The efficacy of the applied therapies based on clinical, radiographical and histological analyses were comparable across all treatment groups. Conclusions: CA microspheres showed longer carrier and bacteriostatic effect sustainability when compared to PG microspheres, however, longer drug sustainability did not lead to improved treatment outcomes.https://www.mdpi.com/1999-4923/12/7/668pharmacodynamicdrug sustainabilitychitosan-alginate microspheresperi-implant mucositislocal minocycline agent |
| spellingShingle | Sung-Wook Yoon Myong-Ji Kim Kyeong-Won Paeng Kyeong Ae Yu Chong-Kil Lee Young Woo Song Jae-Kook Cha Mariano Sanz Ui-Won Jung Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study Pharmaceutics pharmacodynamic drug sustainability chitosan-alginate microspheres peri-implant mucositis local minocycline agent |
| title | Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study |
| title_full | Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study |
| title_fullStr | Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study |
| title_full_unstemmed | Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study |
| title_short | Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study |
| title_sort | locally applied slow release of minocycline microspheres in the treatment of peri implant mucositis an experimental in vivo study |
| topic | pharmacodynamic drug sustainability chitosan-alginate microspheres peri-implant mucositis local minocycline agent |
| url | https://www.mdpi.com/1999-4923/12/7/668 |
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