Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins
Plants containing podophyllotoxin and its analogues have been used as folk medicines for centuries. The characteristic chemical structures and strong biological activities of this class of compounds attracted attention worldwide. Currently, more than ninety natural podophyllotoxins were isolated, an...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/1/302 |
| _version_ | 1797431408632791040 |
|---|---|
| author | Lu Jin Zhijun Song Fang Cai Lijun Ruan Renwang Jiang |
| author_facet | Lu Jin Zhijun Song Fang Cai Lijun Ruan Renwang Jiang |
| author_sort | Lu Jin |
| collection | DOAJ |
| description | Plants containing podophyllotoxin and its analogues have been used as folk medicines for centuries. The characteristic chemical structures and strong biological activities of this class of compounds attracted attention worldwide. Currently, more than ninety natural podophyllotoxins were isolated, and structure modifications of these molecules were performed to afford a variety of derivatives, which offered optimized anti-tumor activity. This review summarized up to date reports on natural occurring podophyllotoxins and their sources, structural modification and biological activities. Special attention was paid to both structural modification and optimized antitumor activity. It was noteworthy that etoposide, a derivative of podophyllotoxin, could prevent cytokine storm caused by the recent SARS-CoV-2 viral infection. |
| first_indexed | 2024-03-09T09:43:30Z |
| format | Article |
| id | doaj.art-437e7e77749a43d3adf724c6ef7dd443 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T09:43:30Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-437e7e77749a43d3adf724c6ef7dd4432023-12-02T00:42:07ZengMDPI AGMolecules1420-30492022-12-0128130210.3390/molecules28010302Chemistry and Biological Activities of Naturally Occurring and Structurally Modified PodophyllotoxinsLu Jin0Zhijun Song1Fang Cai2Lijun Ruan3Renwang Jiang4Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, ChinaGuangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, ChinaGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, College of Pharmacy, Jinan University, Guangzhou 510632, ChinaGuangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, ChinaGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, College of Pharmacy, Jinan University, Guangzhou 510632, ChinaPlants containing podophyllotoxin and its analogues have been used as folk medicines for centuries. The characteristic chemical structures and strong biological activities of this class of compounds attracted attention worldwide. Currently, more than ninety natural podophyllotoxins were isolated, and structure modifications of these molecules were performed to afford a variety of derivatives, which offered optimized anti-tumor activity. This review summarized up to date reports on natural occurring podophyllotoxins and their sources, structural modification and biological activities. Special attention was paid to both structural modification and optimized antitumor activity. It was noteworthy that etoposide, a derivative of podophyllotoxin, could prevent cytokine storm caused by the recent SARS-CoV-2 viral infection.https://www.mdpi.com/1420-3049/28/1/302podophyllotoxinstructural modificationbiological activitiesantitumorantiviral |
| spellingShingle | Lu Jin Zhijun Song Fang Cai Lijun Ruan Renwang Jiang Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins Molecules podophyllotoxin structural modification biological activities antitumor antiviral |
| title | Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins |
| title_full | Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins |
| title_fullStr | Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins |
| title_full_unstemmed | Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins |
| title_short | Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins |
| title_sort | chemistry and biological activities of naturally occurring and structurally modified podophyllotoxins |
| topic | podophyllotoxin structural modification biological activities antitumor antiviral |
| url | https://www.mdpi.com/1420-3049/28/1/302 |
| work_keys_str_mv | AT lujin chemistryandbiologicalactivitiesofnaturallyoccurringandstructurallymodifiedpodophyllotoxins AT zhijunsong chemistryandbiologicalactivitiesofnaturallyoccurringandstructurallymodifiedpodophyllotoxins AT fangcai chemistryandbiologicalactivitiesofnaturallyoccurringandstructurallymodifiedpodophyllotoxins AT lijunruan chemistryandbiologicalactivitiesofnaturallyoccurringandstructurallymodifiedpodophyllotoxins AT renwangjiang chemistryandbiologicalactivitiesofnaturallyoccurringandstructurallymodifiedpodophyllotoxins |