The Effect of Short-Term Physical Activity on Withdrawal Symptoms with or without mPFC Area in Male Rats Influenced by Morphine
Background: Drug addiction is one of the social damages that researchers have tried to find suitable strategies for prevention and treatment of it. Meanwhile, short-term physical activity is acceptable parameter for treatment and prevention of addiction. On the other hand, prefrontal cortex, for a l...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2013-08-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/2674 |
| _version_ | 1827882844264857600 |
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| author | Vajiheh Saedi-Marghmaleki HojjatAllah Alaei Hamid Azizi-Malekabadi |
| author_facet | Vajiheh Saedi-Marghmaleki HojjatAllah Alaei Hamid Azizi-Malekabadi |
| author_sort | Vajiheh Saedi-Marghmaleki |
| collection | DOAJ |
| description | Background: Drug addiction is one of the social damages that researchers have tried to find suitable strategies for prevention and treatment of it. Meanwhile, short-term physical activity is acceptable parameter for treatment and prevention of addiction. On the other hand, prefrontal cortex, for a long time as mediating, is involved in many of the complex behavioral responses, especially those associated with addiction and drug abuse. In this paper, the effects of short-term physical activity (treadmill running) on withdrawal symptom with or without mPFC area have been evaluated.
Methods: This experimental study was done on Wistar rats weighing 250 ± 300 g separated to four groups: control, shame, test 1 and test 2; one of the test groups had surgery and lesion on mPFC area. For studying the effects of short-term physical activity, we used treadmill with adjustable speed of 17 m/minute and a 15-degrees slope; after the injection of three doses of morphine, 10, 20, 40 mg in 9 days and running on the treadmill, in the tenth day, the symptoms of addiction were evaluated.
Findings: The morphine injection and running on the treadmill without mPFC region destruction tended to decreasing morphine tendency. There was a significant difference between the rats, with or without mPFC area, received morphine but did not run on the treadmill in morphine tendency
(P < 0.05).
Conclusion: It seems that short-term physical activity (treadmill running) decreases the tendency of using morphine with mPFC area in comparison with other groups, especially with group operated in their mPFC area. |
| first_indexed | 2024-03-12T19:03:07Z |
| format | Article |
| id | doaj.art-437eb4e0840549f28c049c113c5631d7 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T19:03:07Z |
| publishDate | 2013-08-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-437eb4e0840549f28c049c113c5631d72023-08-02T06:29:13ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2013-08-013124399710061370The Effect of Short-Term Physical Activity on Withdrawal Symptoms with or without mPFC Area in Male Rats Influenced by MorphineVajiheh Saedi-Marghmaleki0HojjatAllah Alaei1Hamid Azizi-Malekabadi2MSc Student, Department of Basic Sciences, Payam-e-Noor University, Isfahan, IranProfessor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Basic Sciences, Islamic Azad University, Khorasgan Branch, Isfahan, IranBackground: Drug addiction is one of the social damages that researchers have tried to find suitable strategies for prevention and treatment of it. Meanwhile, short-term physical activity is acceptable parameter for treatment and prevention of addiction. On the other hand, prefrontal cortex, for a long time as mediating, is involved in many of the complex behavioral responses, especially those associated with addiction and drug abuse. In this paper, the effects of short-term physical activity (treadmill running) on withdrawal symptom with or without mPFC area have been evaluated. Methods: This experimental study was done on Wistar rats weighing 250 ± 300 g separated to four groups: control, shame, test 1 and test 2; one of the test groups had surgery and lesion on mPFC area. For studying the effects of short-term physical activity, we used treadmill with adjustable speed of 17 m/minute and a 15-degrees slope; after the injection of three doses of morphine, 10, 20, 40 mg in 9 days and running on the treadmill, in the tenth day, the symptoms of addiction were evaluated. Findings: The morphine injection and running on the treadmill without mPFC region destruction tended to decreasing morphine tendency. There was a significant difference between the rats, with or without mPFC area, received morphine but did not run on the treadmill in morphine tendency (P < 0.05). Conclusion: It seems that short-term physical activity (treadmill running) decreases the tendency of using morphine with mPFC area in comparison with other groups, especially with group operated in their mPFC area.http://jims.mui.ac.ir/index.php/jims/article/view/2674ExerciseWithdrawal symptommPFCMorphine |
| spellingShingle | Vajiheh Saedi-Marghmaleki HojjatAllah Alaei Hamid Azizi-Malekabadi The Effect of Short-Term Physical Activity on Withdrawal Symptoms with or without mPFC Area in Male Rats Influenced by Morphine مجله دانشکده پزشکی اصفهان Exercise Withdrawal symptom mPFC Morphine |
| title | The Effect of Short-Term Physical Activity on Withdrawal Symptoms with or without mPFC Area in Male Rats Influenced by Morphine |
| title_full | The Effect of Short-Term Physical Activity on Withdrawal Symptoms with or without mPFC Area in Male Rats Influenced by Morphine |
| title_fullStr | The Effect of Short-Term Physical Activity on Withdrawal Symptoms with or without mPFC Area in Male Rats Influenced by Morphine |
| title_full_unstemmed | The Effect of Short-Term Physical Activity on Withdrawal Symptoms with or without mPFC Area in Male Rats Influenced by Morphine |
| title_short | The Effect of Short-Term Physical Activity on Withdrawal Symptoms with or without mPFC Area in Male Rats Influenced by Morphine |
| title_sort | effect of short term physical activity on withdrawal symptoms with or without mpfc area in male rats influenced by morphine |
| topic | Exercise Withdrawal symptom mPFC Morphine |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/2674 |
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