| Summary: | Multiple sclerosis is a chronic demyelinating disease of the central nervous system that can be exacerbated by obesity-induced systemic inflammation. Previous studies have shown that weight loss can improve symptoms of MS. Bariatric surgery and non-surgical methods, like diet therapy, are two common approaches to weight loss. In this systematic review, we have reviewed the effectiveness and safety of surgical and non-surgical methods for weight loss in MS patients. This systematic review was conducted based on PRISMA guidelines. PubMed, Embase, Cochrane, Scopus, Web of Science, Science Direct databases were used. Four articles on bariatric surgery and nine articles on diet therapy were included. Both bariatric surgery and diet therapy are safe and effective methods for weight loss in MS patients as in normal population, and both of them can improve quality of life without exacerbating disease progression. No major complications were reported. However, no studies directly compared these two methods and also there is uncertainty regarding long-term effects. Therefore more studies are needed to compare bariatric surgery with other weight loss methods and also to investigate the effect of these methods on more MS-related outcomes to determine the safest and most effective weight loss method in these patients.
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