Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress
Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/6/1375 |
| _version_ | 1797489654814998528 |
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| author | Giovanni Fajardo Michael Coronado Melia Matthews Daniel Bernstein |
| author_facet | Giovanni Fajardo Michael Coronado Melia Matthews Daniel Bernstein |
| author_sort | Giovanni Fajardo |
| collection | DOAJ |
| description | Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Not all cardiovascular stress is pathologic (e.g., ischemia, pressure overload, cardiotoxins), despite a wealth of studies to this effect. Physiological stress, such as that induced by aerobic exercise, can induce morphologic adaptations that share many common pathways with pathological stress, but in this case result in improved mitochondrial health. Developing a better understanding of the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors will aid in the development of pharmacologic interventions aimed at restoring cellular homeostasis. |
| first_indexed | 2024-03-10T00:20:42Z |
| format | Article |
| id | doaj.art-437fc285240b4e7a9cf0e07b6ce9607e |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:20:42Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-437fc285240b4e7a9cf0e07b6ce9607e2023-11-23T15:43:49ZengMDPI AGBiomedicines2227-90592022-06-01106137510.3390/biomedicines10061375Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological StressGiovanni Fajardo0Michael Coronado1Melia Matthews2Daniel Bernstein3Department of Pediatrics and the Cardiovascular Institute, Stanford University, Stanford, CA 94305, USACytokinetics Inc., South San Francisco, CA 94080, USADepartment of Biomedical and Biological Sciences, Cornell University, Ithaca, NY 14850, USADepartment of Pediatrics and the Cardiovascular Institute, Stanford University, Stanford, CA 94305, USAAlterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Not all cardiovascular stress is pathologic (e.g., ischemia, pressure overload, cardiotoxins), despite a wealth of studies to this effect. Physiological stress, such as that induced by aerobic exercise, can induce morphologic adaptations that share many common pathways with pathological stress, but in this case result in improved mitochondrial health. Developing a better understanding of the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors will aid in the development of pharmacologic interventions aimed at restoring cellular homeostasis.https://www.mdpi.com/2227-9059/10/6/1375mitochondriafissionfusionmitophagybiogenesis |
| spellingShingle | Giovanni Fajardo Michael Coronado Melia Matthews Daniel Bernstein Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress Biomedicines mitochondria fission fusion mitophagy biogenesis |
| title | Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress |
| title_full | Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress |
| title_fullStr | Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress |
| title_full_unstemmed | Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress |
| title_short | Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress |
| title_sort | mitochondrial quality control in the heart the balance between physiological and pathological stress |
| topic | mitochondria fission fusion mitophagy biogenesis |
| url | https://www.mdpi.com/2227-9059/10/6/1375 |
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