Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase
Cardiac surgery involving ischemic arrest and extracorporeal circulation is often associated with alterations in vascular reactivity and permeability due to changes in the expression and activity of isoforms of nitric oxide synthase and cyclooxygenase. These inflammatory changes may manifest as syst...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
1999-11-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100004 |
| _version_ | 1818527268078616576 |
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| author | F.W. Sellke |
| author_facet | F.W. Sellke |
| author_sort | F.W. Sellke |
| collection | DOAJ |
| description | Cardiac surgery involving ischemic arrest and extracorporeal circulation is often associated with alterations in vascular reactivity and permeability due to changes in the expression and activity of isoforms of nitric oxide synthase and cyclooxygenase. These inflammatory changes may manifest as systemic hypotension, coronary spasm or contraction, myocardial failure, and dysfunction of the lungs, gut, brain and other organs. In addition, endothelial dysfunction may increase the occurrence of late cardiac events such as graft thrombosis and myocardial infarction. These vascular changes may lead to increased mortality and morbidity and markedly lengthen the time of hospitalization and cost of cardiac surgery. Developing a better understanding of the vascular changes operating through nitric oxide synthase and cyclooxygenase may improve the care and help decrease the cost of cardiovascular operations. |
| first_indexed | 2024-12-11T06:33:56Z |
| format | Article |
| id | doaj.art-437ff92d35984a13bc1d391c404f3723 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-11T06:33:56Z |
| publishDate | 1999-11-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-437ff92d35984a13bc1d391c404f37232022-12-22T01:17:26ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X1999-11-0132111345135210.1590/S0100-879X1999001100004Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenaseF.W. SellkeCardiac surgery involving ischemic arrest and extracorporeal circulation is often associated with alterations in vascular reactivity and permeability due to changes in the expression and activity of isoforms of nitric oxide synthase and cyclooxygenase. These inflammatory changes may manifest as systemic hypotension, coronary spasm or contraction, myocardial failure, and dysfunction of the lungs, gut, brain and other organs. In addition, endothelial dysfunction may increase the occurrence of late cardiac events such as graft thrombosis and myocardial infarction. These vascular changes may lead to increased mortality and morbidity and markedly lengthen the time of hospitalization and cost of cardiac surgery. Developing a better understanding of the vascular changes operating through nitric oxide synthase and cyclooxygenase may improve the care and help decrease the cost of cardiovascular operations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100004nitric oxide synthasecyclooxygenaseheart surgeryendotheliummicrocirculation |
| spellingShingle | F.W. Sellke Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase Brazilian Journal of Medical and Biological Research nitric oxide synthase cyclooxygenase heart surgery endothelium microcirculation |
| title | Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase |
| title_full | Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase |
| title_fullStr | Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase |
| title_full_unstemmed | Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase |
| title_short | Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase |
| title_sort | vascular changes after cardiopulmonary bypass and ischemic cardiac arrest roles of nitric oxide synthase and cyclooxygenase |
| topic | nitric oxide synthase cyclooxygenase heart surgery endothelium microcirculation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100004 |
| work_keys_str_mv | AT fwsellke vascularchangesaftercardiopulmonarybypassandischemiccardiacarrestrolesofnitricoxidesynthaseandcyclooxygenase |