Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series
We report here four cases of genital ulcers that developed after the administration of all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). Between October 2007 and March 2010, three males and one female (age range 19-35 years) were identified to have genital ulcer...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2013-05-01
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| Series: | Oman Medical Journal |
| Subjects: | |
| Online Access: | http://www.omjournal.org/fultext_PDF.aspx?DetailsID=381&type=fultext |
| _version_ | 1818520915760119808 |
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| author | Mohammed Al Huneini Fauzia Wasim Khalil Al Farsi Murtadha Al-Khabori Salam Al Kindi |
| author_facet | Mohammed Al Huneini Fauzia Wasim Khalil Al Farsi Murtadha Al-Khabori Salam Al Kindi |
| author_sort | Mohammed Al Huneini |
| collection | DOAJ |
| description | We report here four cases of genital ulcers that developed after the administration of all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). Between October 2007 and March 2010, three males and one female (age range 19-35 years) were identified to have genital ulcers after being prescribed all-trans retinoic acid (ATRA) as a part of chemotherapy for APL. This is the first series of cases describing genital ulcers, as a unique and rare complication of ATRA used for treatment of APL in these patients, with no other cause identified. Following temporary cessation of ATRA for a few days in these three cases, improvement of the ulcers was noted. |
| first_indexed | 2024-12-11T01:44:02Z |
| format | Article |
| id | doaj.art-43802748a4914a788bb76a3ce2f77ee8 |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-12-11T01:44:02Z |
| publishDate | 2013-05-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-43802748a4914a788bb76a3ce2f77ee82022-12-22T01:24:57ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042013-05-0128320720910.5001/omj.2013.56Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case SeriesMohammed Al HuneiniFauzia WasimKhalil Al FarsiMurtadha Al-KhaboriSalam Al KindiWe report here four cases of genital ulcers that developed after the administration of all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). Between October 2007 and March 2010, three males and one female (age range 19-35 years) were identified to have genital ulcers after being prescribed all-trans retinoic acid (ATRA) as a part of chemotherapy for APL. This is the first series of cases describing genital ulcers, as a unique and rare complication of ATRA used for treatment of APL in these patients, with no other cause identified. Following temporary cessation of ATRA for a few days in these three cases, improvement of the ulcers was noted.http://www.omjournal.org/fultext_PDF.aspx?DetailsID=381&type=fultextAcute promyelocytic leukaemiaAll-trans retinoic acidFeverScrotal ulcersATRA. |
| spellingShingle | Mohammed Al Huneini Fauzia Wasim Khalil Al Farsi Murtadha Al-Khabori Salam Al Kindi Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series Oman Medical Journal Acute promyelocytic leukaemia All-trans retinoic acid Fever Scrotal ulcers ATRA. |
| title | Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series |
| title_full | Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series |
| title_fullStr | Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series |
| title_full_unstemmed | Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series |
| title_short | Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series |
| title_sort | genital ulcer development in patients with acute promyelocytic leukaemia treated with all trans retinoic acid a case series |
| topic | Acute promyelocytic leukaemia All-trans retinoic acid Fever Scrotal ulcers ATRA. |
| url | http://www.omjournal.org/fultext_PDF.aspx?DetailsID=381&type=fultext |
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