COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study
COVID-19 vaccines have achieved a significant reduction in mortality, yet objective estimates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to Septem...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/5/812 |
| _version_ | 1797494781971005440 |
|---|---|
| author | Mario J. Valladares-Garrido Sandra Zeña-Ñañez C. Ichiro Peralta Jacqueline B. Puicón-Suárez Cristian Díaz-Vélez Virgilio E. Failoc-Rojas |
| author_facet | Mario J. Valladares-Garrido Sandra Zeña-Ñañez C. Ichiro Peralta Jacqueline B. Puicón-Suárez Cristian Díaz-Vélez Virgilio E. Failoc-Rojas |
| author_sort | Mario J. Valladares-Garrido |
| collection | DOAJ |
| description | COVID-19 vaccines have achieved a significant reduction in mortality, yet objective estimates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to September 2021. We included hospitalized patients with COVID-19, whose data were stored in NotiWeb, a patient data system of the Peruvian Ministry of Health. We applied a propensity score-weighting method according to baseline characteristics of patients, and estimated hazard ratios (HR) using Cox regression models. Of 1553 participants, the average age was 55 years (SD: 16.8), 907 (58%) were male, and 592 (38%) deceased at 28-day follow-up. Before hospital admission, 74 (4.8%) had been immunized with at least one vaccine dose. Effectiveness against death in vaccinated patients was 50% at 90-day follow-up (weighted HR 0.50, 95% CI 0.28–0.89). Our results support the effectiveness of COVID-19 vaccination against death and provide information after early immunization in Peru. |
| first_indexed | 2024-03-10T01:39:14Z |
| format | Article |
| id | doaj.art-438101b2653e4010803fadd509703134 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T01:39:14Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-438101b2653e4010803fadd5097031342023-11-23T13:27:39ZengMDPI AGVaccines2076-393X2022-05-0110581210.3390/vaccines10050812COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort StudyMario J. Valladares-Garrido0Sandra Zeña-Ñañez1C. Ichiro Peralta2Jacqueline B. Puicón-Suárez3Cristian Díaz-Vélez4Virgilio E. Failoc-Rojas5Vicerrectorado de Investigación, Universidad Norbert Wiener, Lima 15046, PeruSchool of Medicine, Universidad Continental, Huancayo 12001, PeruSchool of Medicine, Universidad Nacional Federico Villarreal, Lima 15088, PeruSociedad Científica de Estudiantes de Medicina, Universidad Nacional Pedro Ruiz Gallo, Lambayeque 14013, PeruInstituto de Evaluación de Tecnologías en Salud e Investigación-IETSI, EsSalud, Lima 15072, PeruInstituto de Evaluación de Tecnologías en Salud e Investigación-IETSI, EsSalud, Lima 15072, PeruCOVID-19 vaccines have achieved a significant reduction in mortality, yet objective estimates are needed in specific settings. We aimed to determine the effectiveness of COVID-19 vaccination at a referral hospital in Lambayeque, Peru. We conducted a retrospective cohort study from February to September 2021. We included hospitalized patients with COVID-19, whose data were stored in NotiWeb, a patient data system of the Peruvian Ministry of Health. We applied a propensity score-weighting method according to baseline characteristics of patients, and estimated hazard ratios (HR) using Cox regression models. Of 1553 participants, the average age was 55 years (SD: 16.8), 907 (58%) were male, and 592 (38%) deceased at 28-day follow-up. Before hospital admission, 74 (4.8%) had been immunized with at least one vaccine dose. Effectiveness against death in vaccinated patients was 50% at 90-day follow-up (weighted HR 0.50, 95% CI 0.28–0.89). Our results support the effectiveness of COVID-19 vaccination against death and provide information after early immunization in Peru.https://www.mdpi.com/2076-393X/10/5/812vaccinationCOVID-19mortalityvaccine effectivenessPeru |
| spellingShingle | Mario J. Valladares-Garrido Sandra Zeña-Ñañez C. Ichiro Peralta Jacqueline B. Puicón-Suárez Cristian Díaz-Vélez Virgilio E. Failoc-Rojas COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study Vaccines vaccination COVID-19 mortality vaccine effectiveness Peru |
| title | COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study |
| title_full | COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study |
| title_fullStr | COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study |
| title_full_unstemmed | COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study |
| title_short | COVID-19 Vaccine Effectiveness at a Referral Hospital in Northern Peru: A Retrospective Cohort Study |
| title_sort | covid 19 vaccine effectiveness at a referral hospital in northern peru a retrospective cohort study |
| topic | vaccination COVID-19 mortality vaccine effectiveness Peru |
| url | https://www.mdpi.com/2076-393X/10/5/812 |
| work_keys_str_mv | AT mariojvalladaresgarrido covid19vaccineeffectivenessatareferralhospitalinnorthernperuaretrospectivecohortstudy AT sandrazenananez covid19vaccineeffectivenessatareferralhospitalinnorthernperuaretrospectivecohortstudy AT cichiroperalta covid19vaccineeffectivenessatareferralhospitalinnorthernperuaretrospectivecohortstudy AT jacquelinebpuiconsuarez covid19vaccineeffectivenessatareferralhospitalinnorthernperuaretrospectivecohortstudy AT cristiandiazvelez covid19vaccineeffectivenessatareferralhospitalinnorthernperuaretrospectivecohortstudy AT virgilioefailocrojas covid19vaccineeffectivenessatareferralhospitalinnorthernperuaretrospectivecohortstudy |