Insights into early pathogenesis of sporadic Alzheimer’s disease: role of oxidative stress and loss of synaptic proteins

Insights into early pathogenesis of sporadic Alzheimer’s disease: role of oxidative stress and loss of synaptic proteins

Oxidative stress, induced by impaired insulin signaling in the brain contributes to cognitive loss in sporadic Alzheimer’s disease (sAD). This study evaluated early hippocampal oxidative stress, pre- and post-synaptic proteins in intraperitoneal (IP) and intracerebroventricular (ICV) streptozotocin...

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Bibliographic Details
Main Authors: Mubeen A. Ansari, Muddanna Sakkattu Rao, Aishah Al-Jarallah
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Neuroscience
Subjects:
streptozotocin
hyperglycemia
oxidative stress
synaptic proteins
cognitive behavior
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1273626/full

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