Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder characterized by inflammatory arthritis and periarticular structural damage. Available evidence suggests that RA results from complex interactions between genetic susceptibility (e.g., HLA-DRB1), environmental factors (e.g., smokin...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/13/10/1479 |
| _version_ | 1797573293011632128 |
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| author | Michael J. Diaz Nicole Natarelli Aria Wei Michaela Rechdan Elizabeth Botto Jasmine T. Tran Mahtab Forouzandeh Jose A. Plaza Benjamin H. Kaffenberger |
| author_facet | Michael J. Diaz Nicole Natarelli Aria Wei Michaela Rechdan Elizabeth Botto Jasmine T. Tran Mahtab Forouzandeh Jose A. Plaza Benjamin H. Kaffenberger |
| author_sort | Michael J. Diaz |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder characterized by inflammatory arthritis and periarticular structural damage. Available evidence suggests that RA results from complex interactions between genetic susceptibility (e.g., HLA-DRB1), environmental factors (e.g., smoking), and immune dysregulation. Alongside joint-related symptoms, individuals with RA may also experience a wide array of skin issues, including the development of nodules, neutrophilic dermatoses, vasculitis, and vasculopathy. Treatment strategies for these manifestations vary but routinely involve corticosteroids, disease-modifying anti-rheumatic drugs, and biologics, with individualized approaches guided by disease severity. In this review, we provide comprehensive insights into the skin-related issues associated with RA, outlining their clinical characteristics and histopathological findings. Our aim is to facilitate early diagnosis and personalized treatment to improve the quality of life of affected individuals. |
| first_indexed | 2024-03-10T21:07:45Z |
| format | Article |
| id | doaj.art-4384b9bc4d604088ada0d4b997df3d81 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T21:07:45Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-4384b9bc4d604088ada0d4b997df3d812023-11-19T17:02:13ZengMDPI AGJournal of Personalized Medicine2075-44262023-10-011310147910.3390/jpm13101479Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and TreatmentMichael J. Diaz0Nicole Natarelli1Aria Wei2Michaela Rechdan3Elizabeth Botto4Jasmine T. Tran5Mahtab Forouzandeh6Jose A. Plaza7Benjamin H. Kaffenberger8College of Medicine, University of Florida, Gainesville, FL 32610, USAMorsani College of Medicine, University of South Florida, Tampa, FL 33602, USASchool of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USACollege of Medicine, University of Florida, Gainesville, FL 32610, USAMorsani College of Medicine, University of South Florida, Tampa, FL 33602, USASchool of Medicine, Indiana University, Indianapolis, IN 46202, USADepartment of Dermatology, University of Florida, Gainesville, FL 32606, USADepartment of Dermatology, Ohio State University Wexner Medical Center, Columbus, OH 43221, USADepartment of Dermatology, Ohio State University Wexner Medical Center, Columbus, OH 43221, USARheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder characterized by inflammatory arthritis and periarticular structural damage. Available evidence suggests that RA results from complex interactions between genetic susceptibility (e.g., HLA-DRB1), environmental factors (e.g., smoking), and immune dysregulation. Alongside joint-related symptoms, individuals with RA may also experience a wide array of skin issues, including the development of nodules, neutrophilic dermatoses, vasculitis, and vasculopathy. Treatment strategies for these manifestations vary but routinely involve corticosteroids, disease-modifying anti-rheumatic drugs, and biologics, with individualized approaches guided by disease severity. In this review, we provide comprehensive insights into the skin-related issues associated with RA, outlining their clinical characteristics and histopathological findings. Our aim is to facilitate early diagnosis and personalized treatment to improve the quality of life of affected individuals.https://www.mdpi.com/2075-4426/13/10/1479rheumatoid arthritiscutaneous manifestationsvasculopathiesrheumatoid nodulesneutrophilic dermatosessweet syndrome |
| spellingShingle | Michael J. Diaz Nicole Natarelli Aria Wei Michaela Rechdan Elizabeth Botto Jasmine T. Tran Mahtab Forouzandeh Jose A. Plaza Benjamin H. Kaffenberger Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment Journal of Personalized Medicine rheumatoid arthritis cutaneous manifestations vasculopathies rheumatoid nodules neutrophilic dermatoses sweet syndrome |
| title | Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment |
| title_full | Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment |
| title_fullStr | Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment |
| title_full_unstemmed | Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment |
| title_short | Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment |
| title_sort | cutaneous manifestations of rheumatoid arthritis diagnosis and treatment |
| topic | rheumatoid arthritis cutaneous manifestations vasculopathies rheumatoid nodules neutrophilic dermatoses sweet syndrome |
| url | https://www.mdpi.com/2075-4426/13/10/1479 |
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