Menopausal Status Combined with Serum CA125 Level Significantly Predicted Concurrent Endometrial Cancer in Women Diagnosed with Atypical Endometrial Hyperplasia before Surgery <sup>†</sup>
About 10–66% of patients with atypical endometrial hyperplasia diagnosed before surgery (preoperative-AEH) are found to have concurrent endometrial cancer (EC) at definitive hysterectomy, leading to incomplete primary surgery and delayed adjuvant treatment. This study aims to investigate the potenti...
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MDPI AG
2021-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/1/6 |
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| author | Yaochen Lou Jiongbo Liao Weiwei Shan Zhiying Xu Xiaojun Chen Jun Guan |
| author_facet | Yaochen Lou Jiongbo Liao Weiwei Shan Zhiying Xu Xiaojun Chen Jun Guan |
| author_sort | Yaochen Lou |
| collection | DOAJ |
| description | About 10–66% of patients with atypical endometrial hyperplasia diagnosed before surgery (preoperative-AEH) are found to have concurrent endometrial cancer (EC) at definitive hysterectomy, leading to incomplete primary surgery and delayed adjuvant treatment. This study aims to investigate the potential risk factors of concurrent EC in preoperative-AEH patients in a clinical setting with a gynecological pathology review. All patients diagnosed with AEH by endometrial biopsy or curettage that then underwent definitive hysterectomy from January 2016 to December 2019 in a tertiary hospital were retrospectively analyzed. All diagnoses were reviewed by gynecological pathologists. A total of 624 preoperative-AEH patients were included, 30.4% of whom had concurrent EC. In multivariate analysis, postmenopausal status and CA125 ≥ 35 U/mL significantly correlated with concurrent EC (OR = 3.57; 95% CI = 1.80–7.06; OR = 2.15; 95% CI = 1.15–4.03). This risk was remarkably increased in patients with both postmenopausal status and CA125 ≥ 35 U/mL (OR = 16.20; 95% CI = 1.73–151.44). Notably, concurrent EC seemed to occur more frequently in women with postmenopausal time ≥ 5 years (OR = 4.04, 95% CI = 1.80–5.85). In addition, CA125 ≥ 35 U/mL seemed to be an independent risk factor (OR = 5.74; 95% CI = 1.80–18.27) for concurrent intermediate-high-risk EC. Intermediate-high-risk EC was also more commonly seen in preoperative-AEH women with postmenopausal time ≥ 5 years (OR = 5.52, 95% CI = 1.21–25.19, <i>p</i> = 0.027). In conclusion, preoperative-AEH patients with postmenopausal status or elevated level of CA125 might have a high risk of concurrent EC. Adequate pre-surgical evaluation might be suggested for such patients. |
| first_indexed | 2024-03-10T01:39:14Z |
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| language | English |
| last_indexed | 2024-03-10T01:39:14Z |
| publishDate | 2021-12-01 |
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| series | Diagnostics |
| spelling | doaj.art-43852792d1cc454daec0c18b0c0516352023-11-23T13:26:40ZengMDPI AGDiagnostics2075-44182021-12-01121610.3390/diagnostics12010006Menopausal Status Combined with Serum CA125 Level Significantly Predicted Concurrent Endometrial Cancer in Women Diagnosed with Atypical Endometrial Hyperplasia before Surgery <sup>†</sup>Yaochen Lou0Jiongbo Liao1Weiwei Shan2Zhiying Xu3Xiaojun Chen4Jun Guan5Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, ChinaDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, ChinaDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, ChinaDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, ChinaDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, ChinaDepartment of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, ChinaAbout 10–66% of patients with atypical endometrial hyperplasia diagnosed before surgery (preoperative-AEH) are found to have concurrent endometrial cancer (EC) at definitive hysterectomy, leading to incomplete primary surgery and delayed adjuvant treatment. This study aims to investigate the potential risk factors of concurrent EC in preoperative-AEH patients in a clinical setting with a gynecological pathology review. All patients diagnosed with AEH by endometrial biopsy or curettage that then underwent definitive hysterectomy from January 2016 to December 2019 in a tertiary hospital were retrospectively analyzed. All diagnoses were reviewed by gynecological pathologists. A total of 624 preoperative-AEH patients were included, 30.4% of whom had concurrent EC. In multivariate analysis, postmenopausal status and CA125 ≥ 35 U/mL significantly correlated with concurrent EC (OR = 3.57; 95% CI = 1.80–7.06; OR = 2.15; 95% CI = 1.15–4.03). This risk was remarkably increased in patients with both postmenopausal status and CA125 ≥ 35 U/mL (OR = 16.20; 95% CI = 1.73–151.44). Notably, concurrent EC seemed to occur more frequently in women with postmenopausal time ≥ 5 years (OR = 4.04, 95% CI = 1.80–5.85). In addition, CA125 ≥ 35 U/mL seemed to be an independent risk factor (OR = 5.74; 95% CI = 1.80–18.27) for concurrent intermediate-high-risk EC. Intermediate-high-risk EC was also more commonly seen in preoperative-AEH women with postmenopausal time ≥ 5 years (OR = 5.52, 95% CI = 1.21–25.19, <i>p</i> = 0.027). In conclusion, preoperative-AEH patients with postmenopausal status or elevated level of CA125 might have a high risk of concurrent EC. Adequate pre-surgical evaluation might be suggested for such patients.https://www.mdpi.com/2075-4418/12/1/6atypical endometrial hyperplasiaendometrial cancerpostmenopausal statuscancer antigen 125 |
| spellingShingle | Yaochen Lou Jiongbo Liao Weiwei Shan Zhiying Xu Xiaojun Chen Jun Guan Menopausal Status Combined with Serum CA125 Level Significantly Predicted Concurrent Endometrial Cancer in Women Diagnosed with Atypical Endometrial Hyperplasia before Surgery <sup>†</sup> Diagnostics atypical endometrial hyperplasia endometrial cancer postmenopausal status cancer antigen 125 |
| title | Menopausal Status Combined with Serum CA125 Level Significantly Predicted Concurrent Endometrial Cancer in Women Diagnosed with Atypical Endometrial Hyperplasia before Surgery <sup>†</sup> |
| title_full | Menopausal Status Combined with Serum CA125 Level Significantly Predicted Concurrent Endometrial Cancer in Women Diagnosed with Atypical Endometrial Hyperplasia before Surgery <sup>†</sup> |
| title_fullStr | Menopausal Status Combined with Serum CA125 Level Significantly Predicted Concurrent Endometrial Cancer in Women Diagnosed with Atypical Endometrial Hyperplasia before Surgery <sup>†</sup> |
| title_full_unstemmed | Menopausal Status Combined with Serum CA125 Level Significantly Predicted Concurrent Endometrial Cancer in Women Diagnosed with Atypical Endometrial Hyperplasia before Surgery <sup>†</sup> |
| title_short | Menopausal Status Combined with Serum CA125 Level Significantly Predicted Concurrent Endometrial Cancer in Women Diagnosed with Atypical Endometrial Hyperplasia before Surgery <sup>†</sup> |
| title_sort | menopausal status combined with serum ca125 level significantly predicted concurrent endometrial cancer in women diagnosed with atypical endometrial hyperplasia before surgery sup † sup |
| topic | atypical endometrial hyperplasia endometrial cancer postmenopausal status cancer antigen 125 |
| url | https://www.mdpi.com/2075-4418/12/1/6 |
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